ELASTASE ACTIVITY - THE ROLE OF ELASTASE IN AORTIC-ANEURYSM FORMATION
ELASTASE ACTIVITY - THE ROLE OF ELASTASE IN AORTIC-ANEURYSM FORMATION
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DOI：
10.1016/0022-4804(82)90093-2
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发表时间：
1982-01-01
影响因子：
2.2
通讯作者：
CARMACK, C
中科院分区：
文献类型：
--
作者：
BUSUTTIL, RW;RINDERBRIECHT, H;CARMACK, C
研究了从主动脉瘤和动脉硬化闭塞性疾病患者获得的主动脉组织中的弹性蛋白酶活性。动脉瘤组织表现出比动脉硬化主动脉明显更大的活性，并且该活性局限于内膜和内中膜。不伴有闭塞性疾病的患者的动脉瘤比患有闭塞性疾病的患者的动脉瘤更大，并且显示出更高的弹性蛋白酶活性。主动脉的弹性蛋白酶活性可以决定动脉瘤的形成并可以抑制伴随的闭塞性疾病的发展。
Elastase activity was studied in aortic tissue obtained from patients with aortic aneurysm and arteriosclerotic occlusive disease. Aneurysmal tissue demonstrates significantly greater activity than the arteriosclerotic aorta and the activity is localized to the intima and inner media. Aneurysms in patients without concomitant occlusive disease are larger than those in patients with occlusive disease and show greater elastase activity. Elastase activity of the aorta may determine aneurysm formation and may inhibit development of concomitant occlusive disease.