Efficacy of platelet-rich fibrin compared with triamcinolone acetonide as injective therapy in the treatment of symptomatic oral lichen planus: a pilot study
Efficacy of platelet-rich fibrin compared with triamcinolone acetonide as injective therapy in the treatment of symptomatic oral lichen planus: a pilot study
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DOI：
10.1007/s00784-020-03702-w
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发表时间：
2021-01-07
影响因子：
3.4
通讯作者：
Giudice, Amerigo
中科院分区：
文献类型：
--
作者：
Bennardo, Francesco;Liborio, Francesco;Giudice, Amerigo
目的口腔扁平苔藓（Oral lichen planus，OLP）是一种慢性免疫介导的口腔疾病。局部类固醇被认为是治疗OLP疼痛性病变的首选。这个分裂的口研究的目的是比较血小板丰富的纤维蛋白（PRF）和曲安奈德（TA）注射疗法的疗效与症状OLP.Materials和方法的患者症状OLP的参与者被招募在学术医院的Magna Grafos大学卡坦扎罗，意大利。每周一次，持续一个月，患者随机接受一侧颊粘膜0.5 mL TA注射和对侧1 mL PRF注射。结果在最后一次注射后4周，观察到PRF治疗部位的病变范围平均减少59.8%，VAS评分平均减少47.6%; TA治疗部位的病变范围平均减少59.2%，VAS评分平均减少40%。结论PRF能有效减少OLP的病变范围和复发率，其疗效与TA相当。应采用更大的样本量、更长的随访时间和PRF最低有效剂量收集额外数据。
Objectives Oral lichen planus (OLP) is a chronic immune-mediated disease that affects the oral cavity. Topical steroids are considered the treatment of choice for painful lesions of OLP. The aim of this split-mouth study was to compare the efficacy of platelet-rich fibrin (PRF) and triamcinolone acetonide (TA) injective therapies in patients with symptomatic OLP.Materials and methods Participants with symptomatic OLP were recruited in the Academic Hospital of Magna Graecia University of Catanzaro, Italy. Once a week for a month, patients randomly received a 0.5-mL TA injection in one buccal mucosa and 1-mL PRF injection in the opposite side. The measured outcomes were reduction of the lesions area and symptomatology modifications using visual analogue scale (VAS) scoreResults Four weeks after the last injections, an average reduction of 59.8% in the lesion extension and an average reduction of 47.6% in the VAS score for PRF-treated sites were observed; the same variation for TA-treated sites was respectively of 59.2% and 40%. There were no statistically significant differences between the two groups.Conclusions PRF was effective in reducing OLP lesions extension and symptomatology, and it seems to be as effective as TA. Additional data should be collected with a larger sample size, at a longer follow-up and on the PRF lowest effective dose.