Failure of psychosocial stress to induce chronic hypertension in the rat.
Failure of psychosocial stress to induce chronic hypertension in the rat.
复制标题
心理社会压力未能诱发大鼠慢性高血压。
作者：
S. Harrap;W. Louis;A. Doyle
在三个独立的实验中，使用日本自发性高血压和Wistar-Kyoto（SHR-WKY F1）大鼠的Wistar-Kyoto（WKY）、Sprague-Dawley（SD）和F1杂种，研究了在亨利设计的特殊笼子中聚集产生的心理社会应激的影响。每个聚集组都表现出典型的“应激”行为障碍。雄性聚集SD大鼠中观察到肾上腺肥大、血浆肾素活性升高和胃糜烂;而雄性聚集SHR-WKY F1大鼠中观察到肾上腺增大、血浆去甲肾上腺素升高和胃糜烂。然而，任何菌株或每个菌株内的任何亚组均未出现持续高血压。在隔离的SD和SHR-SKY F1大鼠中也观察到胃糜烂，表明大鼠的长期隔离也诱导应激。隔离大鼠也始终保持血压正常。在聚集和分离的雄性SHR-WKY F1大鼠中均发现红细胞压积降低，表明血浆体积增加。我们的结论是，无论是压力，由于社会心理障碍，也不是由于隔离产生慢性高血压的三个品系的大鼠研究。
The effect of psychosocial stress produced by aggregation in a special cage designed by Henry was investigated in three separate experiments using Wistar-Kyoto (WKY), Sprague-Dawley (SD) and F1 hybrids of the Japanese spontaneously hypertensive and Wistar-Kyoto (SHR-WKY F1) rats. Each aggregated group displayed typical 'stressed' behavioural disturbances. Adrenal hypertrophy, elevation of plasma renin activity and gastric erosions were noted in male aggregated SD rats; while adrenal enlargement, elevation of plasma noradrenaline and gastric erosions were found in male aggregated SHR-WKY F1 rats. Sustained hypertension, however, did not develop in any strain nor in any subgroup within each strain. Gastric erosions were also noted in isolated SD and SHR-SKY F1 rats suggesting that long term isolation of rats also induces stress. Isolated rats also remained normotensive throughout. Reduced haematocrit was found in both aggregated and isolated male SHR-WKY F1 rats suggesting increased plasma volume. We conclude that neither stress due to psychosocial disturbances nor that due to isolation produces chronic hypertension in the three strains of rat studied.