Treating human autoimmunity: current practice and future prospects.
Treating human autoimmunity: current practice and future prospects.
复制标题
DOI：
10.1126/scitranslmed.3003504
复制
发表时间：
2012-03-14
影响因子：
17.1
通讯作者：
Abbas AK
中科院分区：
文献类型：
--
作者：
Rosenblum MD;Gratz IK;Paw JS;Abbas AK
Autoimmune diseases are caused by immune cells attacking the host tissues they are supposed to protect. Recent advances suggest that maintaining a balance of effector and regulatory immune function is critical for avoiding autoimmunity. New therapies, including costimulation blockade, regulatory T cell therapy, antigen-specific immunotherapy, and manipulating the interleukin-2 pathway, attempt to restore this balance. This review discusses these advances as well as the challenges that must be overcome to target these therapies to patients suffering from autoimmune disease while avoiding the pitfalls of general immunosuppression.
登录
查看更多内容
影响因子：
3.7
作者：
Hondowicz BD;Schwedhelm KV;Kas A;Tasch MA;Rawlings C;Ramchurren N;McIntosh M;D'Amico LA;Sanda S;Standifer NE;Shendure J;Stone B
通讯作者：
Stone B
影响因子：
45.3
作者：
Aversa, F;Terenzi, A;Martelli, MF
通讯作者：
Martelli, MF
DOI：
10.1056/nejmoa1108188
发表时间：
2011-12-01
期刊：
The New England journal of medicine
影响因子：
--
作者：
Koreth J;Matsuoka K;Kim HT;McDonough SM;Bindra B;Alyea EP 3rd;Armand P;Cutler C;Ho VT;Treister NS;Bienfang DC;Prasad S;Tzachanis D;Joyce RM;Avigan DE;Antin JH;Ritz J;Soiffer RJ
通讯作者：
Soiffer RJ
影响因子：
20.3
作者：
Beriou, Gaelle;Costantino, Cristina M.;Hafler, David A.
通讯作者：
Hafler, David A.
影响因子：
56.9
作者：
LENSCHOW, DJ;ZENG, YJ;BLUESTONE, JA
通讯作者：
BLUESTONE, JA