Reductive Amination Of Aldehydes Using Aminoboranes As Iminium Ion Generators
Reductive Amination Of Aldehydes Using Aminoboranes As Iminium Ion Generators
复制标题
DOI：
10.1055/s-2006-939070
复制
发表时间：
2006-04
期刊：
影响因子：
2
通讯作者：
M. Suginome;Yusuke Tanaka;Tomoaki Hasui
中科院分区：
文献类型：
--
作者：
M. Suginome;Yusuke Tanaka;Tomoaki Hasui
2-二烷基氨基-4H-1,3,2-苯并二氧硼烷是水杨醇衍生的氨基硼烷，在醛与 NaBH 4 的还原胺化中充当高效且温和的亚胺离子发生器。使用二异丙氨基衍生物，包括仲胺和伯胺在内的多种胺和氨可以在非质子有机溶剂中参与还原胺化，而无需使用酸性促进剂。
2-Dialkylamino-4H-1,3,2-benzodioxaborins, salicyl alcohol derived aminoboranes, serve as efficient and mild iminium ion generators in the reductive amination of aldehydes with NaBH 4 . Using a diisopropylamino derivative, a variety of amines including secondary and primary amines, and ammonia can participate to the reductive amination in aprotic organic solvents without the use of acidic promoters.