Centriole assembly and the role of Mps1: defensible or dispensable?
Centriole assembly and the role of Mps1: defensible or dispensable?
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DOI：
10.1186/1747-1028-6-9
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发表时间：
2011-04-14
期刊：
影响因子：
2.3
通讯作者：
Fisk HA
中科院分区：
文献类型：
--
作者：
Pike AN;Fisk HA
Mps1蛋白激酶在中心粒组装中是一个有趣且有争议的参与者。Mps1最初被证明控制芽殖酵母纺锤体极体的复制，它存在于从酵母到人类的真核生物中，线虫C。秀丽线虫是一个显著的例外，并且还显示出调节纺锤体检查点和越来越多的与基因组稳定性相关的细胞功能。虽然它在纺锤体检查点的功能似乎是普遍保守的，在大多数生物体中是必不可少的，但其最初描述的纺锤体极复制功能的保守性已被证明是有争议的，并且不太清楚Mps1是否是芽殖酵母外中心体复制所必需的。最近对Mps1的研究已经确定了Mps1在中心粒组装中至少有两种不同的功能，同时支持了Mps1在该过程中起作用的观点。然而，事实上，至少有一个中心体底物的Mps1是保守的从酵母到人类的磷酸化位点，结合证据表明，精致的控制施加在中心体Mps1水平表明，是必不可少的概念可能不是最重要的区别。
The Mps1 protein kinase is an intriguing and controversial player in centriole assembly. Originally shown to control duplication of the budding yeast spindle pole body, Mps1 is present in eukaryotes from yeast to humans, the nematode C. elegans being a notable exception, and has also been shown to regulate the spindle checkpoint and an increasing number of cellular functions relating to genomic stability. While its function in the spindle checkpoint appears to be both universally conserved and essential in most organisms, conservation of its originally described function in spindle pole duplication has proven controversial, and it is less clear whether Mps1 is essential for centrosome duplication outside of budding yeast. Recent studies of Mps1 have identified at least two distinct functions for Mps1 in centriole assembly, while simultaneously supporting the notion that Mps1 is dispensable for the process. However, the fact that at least one centrosomal substrate of Mps1 is conserved from yeast to humans down to the phosphorylation site, combined with evidence demonstrating the exquisite control exerted over centrosomal Mps1 levels suggest that the notion of being essential may not be the most important of distinctions.
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