Morphogens, their identification and regulation
Morphogens, their identification and regulation
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DOI：
10.1242/dev.01043
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发表时间：
2004-02-01
期刊：
影响因子：
4.6
通讯作者：
Takei, Y
中科院分区：
文献类型：
--
作者：
Tabata, T;Takei, Y
在发育过程中，许多组织的细胞根据由形态发生素的浓度梯度设定的位置信息而分化。形态发生素是从组织的限制区域发出并从其来源扩散以形成浓度梯度的信号分子。由于场中每个细胞的命运取决于形态发生素信号的浓度，梯度预示了发育模式。在这篇文章中，我们描述了形态发生素和它们的功能是如何被识别和分析的，重点是已经被广泛研究的模型系统。
During the course of development, cells of many tissues differentiate according to the positional information that is set by the concentration gradients of morphogens. Morphogens are signaling molecules that emanate from a restricted region of a tissue and spread away from their source to form a concentration gradient. As the fate of each cell in the field depends on the concentration of the morphogen signal, the gradient prefigures the pattern of development. In this article, we describe how morphogens and their functions have been identified and analyzed, focusing on model systems that have been extensively studied.