Effect of tandospirone on sleep latency in rats placed on a grid suspended over water.
Effect of tandospirone on sleep latency in rats placed on a grid suspended over water.
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DOI：
10.1254/jphs.fp0070981
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发表时间：
2007
影响因子：
3.5
通讯作者：
Yoshiaki Utsu;K. Shinomiya;S. Tokunaga;Asae Ohmori;C. Kamei
中科院分区：
文献类型：
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作者：
Yoshiaki Utsu;K. Shinomiya;S. Tokunaga;Asae Ohmori;C. Kamei
本研究通过将大鼠放置在悬浮在水面上的网格上来检查坦度螺酮对新失眠动物模型睡眠潜伏期的影响。为了研究坦度螺酮的作用机制，还使用对氯苯丙氨酸给药后神经元血清素 (5-HT) 耗尽的大鼠研究了坦度螺酮对睡眠潜伏期的影响。坦度螺酮导致睡眠潜伏期缩短，且呈剂量依赖性，口服 20 mg/kg 时观察到显着效果。或更多。通过连续 2 天给予对氯苯丙氨酸（300 mg/kg，腹腔注射）观察到睡眠潜伏期缩短。另一方面，坦度螺酮对于缩短由对氯苯丙氨酸引起的睡眠潜伏期没有产生增强作用。根据这些发现，坦度螺酮引起的睡眠潜伏期缩短可能是通过大鼠突触前 5-HT(1A) 受体发生的。
The present study was performed to examine the effect of tandospirone on sleep latency in a new insomnia animal model by placing rats on a grid suspended over water. For investigating the mechanism of tandospirone, the effect of tandospirone on sleep latency was also studied using rats that were depleted with neuronal serotonin (5-HT) after p-chlorophenylalanine administration. Tandospirone caused a shortening of sleep latency dose-dependently, and a significant effect was observed at 20 mg/kg, p.o. or more. A shortening of sleep latency was observed by administration of p-chlorophenylalanine (300 mg/kg, i.p.) for 2 days. On the other hand, tandospirone exerted no potentiating effect on the shortening of sleep latency induced by p-chlorophenylalanine. From these findings, a shortening of sleep latency induced by tandospirone may occur through the pre-synaptic 5-HT(1A) receptors in rats.