Missing in action: enzyme functional annotations in biological databases
Missing in action: enzyme functional annotations in biological databases
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DOI：
10.1038/nchembio0809-521
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发表时间：
2009-08-01
影响因子：
14.8
通讯作者：
Thornton, Janet M.
中科院分区：
文献类型：
--
作者：
Furnham, Nicholas;Garavelli, John S.;Thornton, Janet M.
酶功能注释为生成和测试生物学假设提供了关键起点，但功能注释的质量受到未表征序列的不确定分配以及经过验证的实验数据相对稀疏的阻碍。鉴于基因组数据的不断增加，迫切需要新的思维和验证方法来为酶功能分配提供高可信度。
Annotations of enzyme function provide critical starting points for generating and testing biological hypotheses, but the quality of functional annotations is hindered by uncertain assignments for uncharacterized sequences and by the relative sparseness of validated experimental data. Given the relentless increase in genomic data, new thinking and validation methods are urgently needed to provide high confidence in enzyme functional assignments.