Oxidative Stress in Intracerebral Hemorrhage: Sources, Mechanisms, and Therapeutic Targets.
Oxidative Stress in Intracerebral Hemorrhage: Sources, Mechanisms, and Therapeutic Targets.
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DOI：
10.1155/2016/3215391
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发表时间：
2016
影响因子：
--
通讯作者：
You C
中科院分区：
文献类型：
--
作者：
Hu X;Tao C;Gan Q;Zheng J;Li H;You C
脑出血（ICH）与最高的死亡率和发病率相关，尽管仅占所有卒中的约10-15%。由实质内血液的细胞毒性、兴奋性毒性和炎症作用组成的复杂潜在机制是其高度损伤作用的原因。氧化应激（OS）在脑出血后脑损伤中也起着重要作用，但与其他因素相比受到的关注较少。越来越多的证据表明，血红蛋白-血红素-铁代谢轴是脑出血后氧化性脑损伤的关键因素，尽管其他因素，如神经炎症和氧化酶原，也参与其中。本文就脑出血并发OS的来源、可能的分子机制和潜在的治疗靶点进行综述。
Intracerebral hemorrhage (ICH) is associated with the highest mortality and morbidity despite only constituting approximately 10–15% of all strokes. Complex underlying mechanisms consisting of cytotoxic, excitotoxic, and inflammatory effects of intraparenchymal blood are responsible for its highly damaging effects. Oxidative stress (OS) also plays an important role in brain injury after ICH but attracts less attention than other factors. Increasing evidence has demonstrated that the metabolite axis of hemoglobin-heme-iron is the key contributor to oxidative brain damage after ICH, although other factors, such as neuroinflammation and prooxidases, are involved. This review will discuss the sources, possible molecular mechanisms, and potential therapeutic targets of OS in ICH.
影响因子：
2.1
作者：
Chen-Roetling, Jing;Li, Zhi;Regan, Raymond F.
通讯作者：
Regan, Raymond F.