Leisure-Time Physical Activity in Pregnancy and Risk of Postpartum Depression: A Prospective Study in a Large National Birth Cohort
Leisure-Time Physical Activity in Pregnancy and Risk of Postpartum Depression: A Prospective Study in a Large National Birth Cohort
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DOI：
10.4088/jcp.09m05012blu
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发表时间：
2009-12-01
影响因子：
5.3
通讯作者：
Olsen, Sjurdur F.
中科院分区：
文献类型：
--
作者：
Strom, Marin;Mortensen, Erik L.;Olsen, Sjurdur F.
目的：在一个大型的前瞻性队列中探讨孕期体力活动与产后抑郁症（PPD）之间的关系。方法：来自丹麦国家出生队列的暴露信息，这是一个大型前瞻性队列，包含超过100，000例妊娠的信息（1996-2002年），与丹麦精神病学中央登记处和丹麦医药产品统计登记处联系，以获得临床确定的抑郁症唇至产后1年。来自丹麦国家出生队列的70 866名妇女被纳入分析。在妊娠第12周左右通过电话访谈评估体力活动的持续时间、频率和类型。入院治疗抑郁症（PPD入院）和处方的抗抑郁药（PPD处方）被视为单独outcome.Results：通过链接到国家注册，我们确定了157例PPD入院和1,305例PPD处方。在怀孕期间从事剧烈体力活动的女性与不从事体力活动的女性相比，患PPD处方的风险较低（调整后的比值比，0.81; 95%CI，0.66-0.99）。体力活动和产后抑郁症入院之间没有观察到任何关联，但是，在妇女体重不足怀孕前，体力活动与产后抑郁症入院的风险增加。结论：我们的数据是兼容的保护作用，剧烈的体力活动，但不是其他措施的体力活动，对产后抑郁症需要抗抑郁治疗。未检测到对导致住院的PPD的保护作用。
Objective: To explore the association between physical activity during pregnancy and postpartum depression (PPD) in a large, prospective cohort.Method: Exposure information from the Danish National Birth Cohort, a large, prospective cohort with information on more than 100,000 pregnancies (1996-2002), was linked to the Danish Psychiatric Central Register and the Danish Register for Medicinal Product Statistics for data on clinically identified cases of depression Lip to 1 year postpartum. A total of 70,866 women from the Danish National Birth Cohort were included in the analyses. Duration, frequency, and type of physical activity were assessed by a telephone interview at approximately week 12 of gestation. Admission to hospital due to depression (PPD-admission) and prescription of an antidepressant (PPD-prescription) were treated as separate outcomes.Results: Through linkage to national registers, we identified 157 cases of PPD-admission and 1,305 cases of PPD-prescription. Women engaging in vigorous physical activity during pregnancy had a lower risk of PPD-prescription compared to women who were not physically active (adjusted odds ratio, 0.81; 95% CI, 0.66-0.99). No association was observed between physical activity and PPD-admission; but, in women who were underweight prior to pregnancy, physical activity was associated with increased risk of PPD-admission.Conclusions: Our data are compatible with a protective effect of vigorous physical activity, but not for other measures of physical activity, against postpartum depression requiring antidepressant therapy. No protective effect could be detected on PPD leading to hospitalization.