The effect of recurrent mutation on the linkage disequilibrium under a selective sweep
The effect of recurrent mutation on the linkage disequilibrium under a selective sweep
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DOI：
10.1007/s00285-011-0411-y
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发表时间：
2011-02
影响因子：
1.9
通讯作者：
C. Pokalyuk
中科院分区：
文献类型：
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作者：
C. Pokalyuk
选择性扫描描述了由于强正向选择而导致的多样性的降低。彭宁斯和赫米森(Mol Biol Evol 23(5)：1076-1084,2006a)已经证明，如果选择性有益等位基因的突变率足够高，那么选择性扫描很可能是由几个人引起的。这样的事件被称为软扫描和有益等位基因单一起源的互补事件，典型的情况是硬扫描。根据Ohta和Kimura(Genetics 63(1)：229-238,1969)对有益等位基因Bydand的重复突变，我们给出了与所选基因连锁的两个中性基因座之间的连锁不平衡(LD)的解析表达式，并得出结论：由于单倍型结构，软扫描和硬扫描的连锁不平衡模式有很大的不同。将分析结果与仿真结果进行了比较。
A selective sweep describes the reduction of diversity due to strong positive selection. If the mutation rate to a selectively beneficial allele is sufficiently high, Pennings and Hermisson (Mol Biol Evol 23(5):1076–1084, 2006a) have shown, that it becomes likely, that a selective sweep is caused by several individuals. Such an event is called a soft sweep and the complementary event of a single origin of the beneficial allele, the classical case, a hard sweep. We give analytical expressions for the linkage disequilibrium (LD) between two neutral loci linked to the selected locus, depending on the recurrent mutation to the beneficial allele, measured byDand, a quantity introduced by Ohta and Kimura (Genetics 63(1):229–238, 1969), and conclude that the LD-pattern of a soft sweep differs substantially from that of a hard sweep due to haplotype structure. The analytical results are compared with simulations.