Specificity of cone inputs to macaque retinal ganglion cells
Specificity of cone inputs to macaque retinal ganglion cells
复制标题
DOI：
10.1152/jn.00714.2005
复制
发表时间：
2006-02-01
影响因子：
2.5
通讯作者：
Lee, BB
中科院分区：
文献类型：
--
作者：
Sun, H;Smithson, HE;Lee, BB
视锥细胞对神经节细胞的特异性输入对视网膜连接的发展和传递到大脑更高区域的信息的性质具有影响。我们介绍了一种快速和精确的方法来测量信号和大小的锥输入到视觉神经元。刺激的颜色在三个颜色平面的圆周上沿顺时针和逆时针方向调制。对于每个神经元，通过对顺时针和逆时针调制的响应相位进行平均来估计每个平面中优选向量的投影。锥输入的符号和权重直接从优选向量导出。该方法的效率，使我们能够测量锥输入在不同的时间频率和短波长敏感（S）锥适应水平。结果表明，小细胞和大细胞神经节细胞的S-锥输入是可以忽略不计的，这意味着潜在的连接特异性在视网膜电路。
The specificity of cone inputs to ganglion cells has implications for the development of retinal connections and the nature of information transmitted to higher areas of the brain. We introduce a rapid and precise method for measuring signs and magnitudes of cone inputs to visual neurons. Colors of stimuli are modulated around circumferences of three color planes in clockwise and counterclockwise directions. For each neuron, the projection of the preferred vector in each plane was estimated by averaging the response phases to clockwise and counterclockwise modulation. The signs and weights of cone inputs were derived directly from the preferred vectors. The efficiency of the method enables us to measure cone inputs at different temporal frequencies and short-wavelength-sensitive (S) cone adaptation levels. The results show that S-cone inputs to the parvocellular and magnocellular ganglion cells are negligible, which implies underlying connectional specificity in the retinal circuitry.