Phytate reduces age-related cardiovascular calcification
Phytate reduces age-related cardiovascular calcification
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DOI：
10.2741/3214
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发表时间：
2008-05-01
影响因子：
3.1
通讯作者：
Saus, Carles
中科院分区：
文献类型：
--
作者：
Grases, Felix;Sanchis, Pilar;Saus, Carles
本研究的目的是评价膳食植酸对衰老过程中大鼠心血管钙化的影响。雄性Wistar大鼠(10周龄)随机分为4组。对照组饲喂含有植酸的均衡饲料(UAR-A04)。AIN组喂食纯饲料(AIN-76A)，其中植酸水平检测不到。PHY组饲喂纯饲料(AIN-76A)，富含植酸盐(植酸钙镁盐)。MOD组饲喂AIN-76A饲料(未检测到植酸盐)，富含镁、肌醇和磷酸二氢钙。在76周龄时，所有大鼠被处死，取主动脉、心脏、肾脏、肝脏和股骨进行化学分析。其中以主动脉钙含量差异最显著。植酸处理的大鼠(对照组和PHY组)与非植酸处理的大鼠(AIN和MOD组)相比，主动脉中的钙水平显著降低。目前的研究表明，饮食植酸盐治疗显著减少了与年龄相关的主动脉钙化。
The aim of this research was to evaluate the effect of dietary phytate on cardiovascular calcification in rats during aging. Male Wistar rats (10 weeks old) were randomly assigned to four diet groups. The control group was fed with a balanced diet (UAR-A04) containing phytate. The AIN group was fed a purified diet (AIN-76A) with an undetectable level of phytate. The PHY group was fed with a purified diet (AIN-76A) enriched with phytate (phytin, as the calcium magnesium salt). The MOD group was fed with the AIN-76A diet (phytate undetectable) enriched with MgO, inositol and CaHPO4. At 76 weeks of age all rats were sacrificed, and the aortas, hearts, kidneys, livers and femurs were removed for chemical analysis. The most significant differences were found in the aorta calcium content. Phytate-treated rats (the control and PHY groups) had significantly lower levels of calcium in the aorta compared to nonphytate-treated rats (AIN and MOD groups). The present study demonstrated that dietary phytate treatment significantly reduced age-related aorta calcification.