Rapid molecular evolution of CYCLOIDEA-like genes in antirrhinum and its relatives
Rapid molecular evolution of CYCLOIDEA-like genes in antirrhinum and its relatives
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DOI：
10.1093/molbev/msg166
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发表时间：
2003-09-01
影响因子：
10.7
通讯作者：
Hudson, A
中科院分区：
文献类型：
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作者：
Gübitz, T;Caldwell, A;Hudson, A
CYCLOIDEA (CYC) 和 DICHOTOMA (DICH) 基因编码相关的 TCP 转录因子，控制金鱼草花的不对称性。对金鱼草近缘种的序列分析表明，CYC 和 DICH 源自金鱼草部落祖先的基因复制，随后以相似的速率进化。保守功能 TCP 和 R 结构域之外的编码区域存在大量插入缺失，表明进化速度快且对氨基酸序列的限制较低。对金鱼草属内变异性的分析显示，17 个代表性物种的 CYC 等位基因非常相似，这与大多数物种在过去 1 myr 内发生分化的情况一致。尽管替代突变似乎不断积累，但金鱼草 CYC 等位基因为插入突变的零星且快速积累提供了证据。
The CYCLOIDEA (CYC) and DICHOTOMA (DICH) genes encode related TCP transcription factors that control floral asymmetry in Antirrhinum majus. Analysis of sequences from relatives of Antirrhinum suggested that CYC and DICH arose from a gene duplication in an ancestor of the tribe Antirrhineae and have subsequently evolved at similar rates. Coding regions outside the conserved functional TCP and R domains differed by numerous indels, suggesting rapid evolution and low constraint on amino acid sequence. An analysis of variability within the genus Antirrhinum revealed very similar CYC alleles in 17 representative species, consistent with most of the species having diverged within the last 1 myr. Whereas substitution mutations appear to have accumulated constantly, one Antirrhinum CYC allele provided evidence for sporadic and rapid accumulation of insertion mutations.