EVOLUTIONARY AND SOMATIC SELECTION OF THE ANTIBODY REPERTOIRE IN THE MOUSE
EVOLUTIONARY AND SOMATIC SELECTION OF THE ANTIBODY REPERTOIRE IN THE MOUSE
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DOI：
10.1126/science.3317826
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发表时间：
1987-11-20
期刊：
影响因子：
56.9
通讯作者：
CUMANO, A
中科院分区：
文献类型：
--
作者：
RAJEWSKY, K;FORSTER, I;CUMANO, A
抗体可变区(V)区的谱系受到进化选择的影响，既影响种系中V区基因的多样性，也影响它们在B淋巴细胞及其亚群中的表达。在个体发育中，与抗原接触会导致表达与其互补的抗体的B细胞的扩张。在B细胞分化的特定阶段，通过体细胞超突变，从现有的谱系中产生新的V区集合。携带有利抗体突变体的细胞被选择进入记忆室，并在再次暴露于抗原时产生稳定的二次反应。
The repertoire of antibody variable (V) regions has been subject to evolutionary selection, affecting both the diversity of V region genes in the germline and their expression in the B lymphocyte population and its subsets. In ontogeny, contact with an antigen leads to the expansion of B cells expressing antibodies complementary to it. In a defined phase of B cell differentiation, new sets of V regions are generated from the existing repertoire through somatic hypermutation. Cells carrying advantageous antibody mutants are selected into the memory compartment and produce a stable secondary response upon reexposure to the antigen.