Dorsal hippocampal NMDA receptor blockade impairs extinction of naloxone‐precipitated conditioned place aversion in acute morphine‐treated rats by suppressing ERK and CREB phosphorylation in the basolateral amygdala
Dorsal hippocampal NMDA receptor blockade impairs extinction of naloxone‐precipitated conditioned place aversion in acute morphine‐treated rats by suppressing ERK and CREB phosphorylation in the basolateral amygdala
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DOI:
10.1111/bph.12671
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发表时间:
2015-01
影响因子:
7.3
通讯作者:
Weisheng Wang;Zhong Chen;Wen‐Tao Liu;Z. Chi;Ling He;Jing-gen Liu
中科院分区:
文献类型:
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作者:
Weisheng Wang;Zhong Chen;Wen‐Tao Liu;Z. Chi;Ling He;Jing-gen Liu
Substantial evidence shows that negative reinforcement resulting from the aversive affective consequences of opiate withdrawal may play a crucial role in drug relapse. Understanding the mechanisms underlying the loss (extinction) of conditioned aversion of drug withdrawal could facilitate the treatment of drug addiction.