Optimal cellular mobility for synchronization arising from the gradual recovery of intercellular interactions
Optimal cellular mobility for synchronization arising from the gradual recovery of intercellular interactions
复制标题
由于细胞间相互作用的逐渐恢复而产生最佳的细胞同步移动性
DOI：
10.1088/1478-3975/9/3/036006
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发表时间：
2012
期刊：
影响因子：
2
通讯作者：
Luis G. Morelli
中科院分区：
文献类型：
--
作者：
Koichiro Uriu;Saul Ares;Andrew C. Oates;Luis G. Morelli
在组织发育过程中，细胞运动和细胞间信号传导同时发生，但人们对运动如何影响信号传导知之甚少。先前的理论研究表明，移动速度更快的细胞有利于局部耦合遗传振荡器群体的同步。这些研究中的一个重要假设是，细胞在到达新位置后可以立即与新邻居相互作用。然而，细胞系统中的细胞间相互作用可能需要一些时间才能完全建立。在这种情况下运动如何影响同步尚未得到研究。在这里，我们开发了一个耦合相位振荡器模型，其中我们考虑细胞运动和运动后细胞经历的细胞间耦合的逐渐恢复，分别以移动速率和耦合恢复速率为特征。我们找到（1）同步的最佳移动速率和（2）临界移动速率，高于该速率就不可能实现同步。这些结果表明，运动增强同步性的程度受到耦合逐渐恢复的限制。这些发现表明运动和信号恢复的时间尺度之比对于运动细胞之间的信息传递至关重要。
Cell movement and intercellular signaling occur simultaneously during the development of tissues, but little is known about how movement affects signaling. Previous theoretical studies have shown that faster moving cells favor synchronization across a population of locally coupled genetic oscillators. An important assumption in these studies is that cells can immediately interact with their new neighbors after arriving at a new location. However, intercellular interactions in cellular systems may need some time to become fully established. How movement affects synchronization in this situation has not been examined. Here, we develop a coupled phase oscillator model in which we consider cell movement and the gradual recovery of intercellular coupling experienced by a cell after movement, characterized by a moving rate and a coupling recovery rate, respectively. We find (1) an optimal moving rate for synchronization and (2) a critical moving rate above which achieving synchronization is not possible. These results indicate that the extent to which movement enhances synchrony is limited by a gradual recovery of coupling. These findings suggest that the ratio of time scales of movement and signaling recovery is critical for information transfer between moving cells.