Endothelial colony-forming cell role in neoangiogenesis and tissue repair.
Endothelial colony-forming cell role in neoangiogenesis and tissue repair.
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DOI：
10.1097/mot.0b013e32833454b5
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发表时间：
2010-02
影响因子：
2.2
通讯作者：
Yoder MC
中科院分区：
文献类型：
--
作者：
Critser PJ;Yoder MC
患有血管疾病的患者通常血管生成能力受损，导致组织修复受损。一种潜在的治疗方法是输送有助于血管生成的细胞。本文将讨论内皮祖细胞（endothelial progenitor cells， EPC）在生理和病理条件下促进新生血管生成的能力，并在组织修复中促进新生血管生成。近年来，各种报告描述了EPC在船舶建造中的相互矛盾的作用。目前有三种不同的测定EPC生长的方法，它们都分离出不同的细胞群。这种混淆部分是由于假定的EPC种群的功能特征有限。一个种群，ECFC，已被证明具有真正内皮祖细胞的所有特征。本文综述了推定的EPC群体在血管生成和组织修复中的作用。虽然所有的EPC群体都被证明在血管生成中发挥作用，但只有ECFC被证明能够在体内形成新生血管。此外，在一些临床前啮齿动物模型中，ECFC已被证明在新生血管中发挥作用，这表明它可能是治疗血管功能减退患者的良好细胞来源。
Patients suffering from vascular disease often have impaired angiogenic ability contributing to impaired tissue repair. One potential therapy is to deliver cells that can aid in angiogenesis. This review will discuss the ability of endothelial progenitor cells (EPC), which have been reported to contribute to neoangiogenesis in both physiological and pathological conditions, to contribute to neoangiogenesis in tissue repair. In recent years, various reports have described conflicting roles for EPC in vessel formation. Currently there are three different assays for outgrowth of EPC all resulting in the isolation of different cell populations. This confusion is partially due to limited functional characterization of putative EPC populations. One population, ECFC, have been shown to possess all the characteristics of a true endothelial progenitor. The review overviews the role of putative EPC populations in angiogenesis and tissue repair. While all EPC populations have been shown to play a role in angiogenesis, only ECFC have demonstrated the ability to form de novo blood vessels in vivo. Additionally ECFC have been shown to play a role in neovascularization in several pre-clinical rodent models suggesting the may be an excellent cell source for treatment of patients with diminished vascular function.