Taking KLF9 to "Cort" for crimes against metabolism.
Taking KLF9 to "Cort" for crimes against metabolism.
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DOI：
10.1172/jci128481
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发表时间：
2019-04
期刊：
影响因子：
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通讯作者：
David R. Sweet;Liyan Fan;M. Jain
中科院分区：
文献类型：
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作者：
David R. Sweet;Liyan Fan;M. Jain
糖皮质激素（GC）对于适当的血糖控制至关重要，但过量可导致高血糖症和糖尿病。在本期JCI中，Cui等人阐明了GC在生理和疾病环境中利用转录因子Krüppel样因子9（KLF 9）调节糖异生的机制。他们报告说，KLF9是一种GC诱导因子，最终增加增殖物激活受体γ共激活因子1 α（PGC1α）的转录，导致肿瘤异生。鉴于GC诱导的糖尿病的高发病率，该信号传导轴的鉴定不仅提供了关键的科学见解，而且为接受慢性GC治疗的患者提供了预防性治疗的基础。
Glucocorticoids (GCs) are essential for proper glycemic control, but in excess, can lead to hyperglycemia and diabetes. In this issue of the JCI, Cui et al. elucidate a mechanism by which GCs regulate gluconeogenesis utilizing the transcription factor Krüppel-like factor 9 (KLF9) in physiology and disease settings. They report that KLF9 is a GC-inducible factor that ultimately increases the transcription of proliferator-activated receptor γ coactivator 1 α (PGC1α), resulting in gluconeogenesis. Given the high incidence of GC-induced diabetes, identification of this signaling axis provides, not only critical scientific insight, but also a foundation for preventative therapies for patients receiving chronic GC treatment.