IDENTIFICATION OF THE PUTATIVE TRANSFORMING PROTEIN OF THE HUMAN T-CELL LEUKEMIA VIRUSES HTLV-I AND HTLV-II
IDENTIFICATION OF THE PUTATIVE TRANSFORMING PROTEIN OF THE HUMAN T-CELL LEUKEMIA VIRUSES HTLV-I AND HTLV-II
复制标题
DOI：
10.1126/science.6089351
复制
发表时间：
1984-01-01
期刊：
影响因子：
56.9
通讯作者：
CHEN, ISY
中科院分区：
文献类型：
--
作者：
SLAMON, DJ;SHIMOTOHNO, K;CHEN, ISY
人类T细胞白血病病毒[HTLV-I和HTLV-II]在脊椎动物的转化逆转录病毒中具有独特的体外转化人类T细胞的能力，并且与人类恶性肿瘤（T细胞淋巴瘤和白血病）密切相关。它们的基因组相对简单，包含gag、pol、env基因和一个称为x的3英寸区域，这个3英寸区域可能负责病毒的转化潜力。在多个开放阅读框的基础上，假设3”区编码的蛋白质存在。在HTLV-I和HTLV-II中，该区域含有一个编码蛋白的基因，分别为40千道尔顿和37千道尔顿。这些蛋白分别被称为p40xI和p37xII。
The human T-cell leukemia viruses [HTLV-I and HTLV-II] are unique among the transforming retroviruses of vertebrates in their ability to transform human T cells in vitro and in their close association with human malignancies (T-cell lymphomas and leukemia). Their genomes are relatively simple, containing the genes gag, pol, env and a 3'' region termed X. This 3'' region may be responsible for the transforming potential of the viruses. The existence of proteins encoded by the 3'' region was postulated on the basis of multiple open reading frames. This region was shown to contain a gene encoding a protein of 40 kilodaltons in HTLV-I and 37 kilodaltons in HTLV-II. It is proposed that these proteins be called, respectively, p40xI and p37xII.