Novel Prognostic Implications of Methylated RNA and Demethylases in Resected HCC and Background Liver Tissue
Novel Prognostic Implications of Methylated RNA and Demethylases in Resected HCC and Background Liver Tissue
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DOI：
10.21873/anticanres.14690
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发表时间：
2020-12-01
影响因子：
2
通讯作者：
Kodera, Yasuhiro
中科院分区：
文献类型：
--
作者：
Nakagawa, Nobuhiko;Tanaka, Katsuhito;Kodera, Yasuhiro
Background/Aim: N6-Methyladenosine (m6A), the most abundant internal modification of RNA, plays a critical role in cancer development. However, the clinical implications of m6A in hepatocellular carcinoma (HCC) remain unclear. Materials and Methods: We analyzed 177 HCC and paired non-cancerous liver tissues from patients who underwent hepatectomy according to global m6A quantification and expression of m6A demethylases fat mass and obesity-associated protein (FTO) and alpha-ketoglutarate-dependent dioxygenase alkB homolog 5 (ALKBH5). Results: The global m6A quantification revealed no significant difference between HCC and non-cancerous tissue. The expression of m6A demethylases FTO and ALKBH5, was significantly lower in HCC than in non-cancerous tissues (both p
