Relation of serum vitamins A and E and carotenoids to the risk of cancer.
Relation of serum vitamins A and E and carotenoids to the risk of cancer.
复制标题
血清维生素 A 和 E 以及类胡萝卜素与癌症风险的关系。
DOI：
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发表时间：
1984
影响因子：
158.5
通讯作者：
C. Hames
中科院分区：
文献类型：
--
作者：
W. Willett;B. Polk;B. Underwood;M. Stampfer;S. Pressel;B. Rosner;JamesO Taylor;K. Schneider;C. Hames
流行病学研究表明，胡萝卜素摄入量低和血清视黄醇水平低可能与癌症风险增加有关。同样，在一些动物研究中，维生素E与诱发癌症的发生率降低有关。因此，我们测量了1973年从高血压检测和随访计划的111名参与者中收集的血清中的视黄醇，视黄醇结合蛋白，维生素E（α-生育酚）和总类胡萝卜素，这些参与者当时没有癌症，但在随后的五年中被诊断为患有癌症。这些测量结果与210名年龄、性别、种族和采血时间相匹配的对照组进行了比较，这些对照组没有癌症。病例组和对照组的视黄醇平均值相似（分别为67.3和68.7微克/分升[病例对照差异的95%置信限为-6.7至3.5]）。视黄醇结合蛋白（6.01和5.94毫克/分升[-0.42至0.56]）和类胡萝卜素（114.5和111.6微克/分升[-9.1至15.9]）的值也相似。18名后来患肺癌的受试者的平均基线视黄醇水平高于其匹配的对照组（79.0 vs. 71.4微克/分升，-4.9至19.7）。后来患癌症的受试者的血清维生素E水平略低于对照组（1.16和1.26 mg/dl，-0.22至0.02），部分原因是血清胆固醇水平的混杂效应（当调整脂质水平时，病例对照差异为-0.05 mg/dl; -0.17至0.07）。这些数据并不支持将抗氧化维生素的摄入量或血清水平与降低癌症风险相关的假设。
Epidemiologic studies suggest that low carotene intake and low levels of serum retinol may be associated with an increased risk of cancer. Likewise, in some animal studies vitamin E has been associated with a reduced rate of induced cancers. Therefore, we measured retinol, retinol-binding protein, vitamin E (alpha-tocopherol), and total carotenoids in serum collected in 1973 from 111 participants in the Hypertension Detection and Follow-up Program who were free of cancer at the time but were diagnosed as having cancer during the subsequent five years. These measurements were compared with those in 210 controls who were matched for age, sex, race, and time of blood collection, and who remained free of cancer. Mean values for retinol were similar for cases and controls (67.3 and 68.7 micrograms per deciliter, respectively [95 per cent confidence limits for case-control difference, -6.7 to 3.5]). Values were also similar for retinol-binding protein (6.01 and 5.94 mg per deciliter [-0.42 to 0.56]), and carotenoids (114.5 and 111.6 micrograms per deciliter [-9.1 to 15.9]). The mean base-line retinol level in the 18 subjects with subsequent lung cancer was higher than that in their matched controls (79.0 vs. 71.4 micrograms per deciliter, -4.9 to 19.7). Serum vitamin E levels were somewhat lower in subjects who later had cancer than in controls (1.16 and 1.26 mg per deciliter, -0.22 to 0.02), in part because of the confounding effect of serum cholesterol levels (when adjusted for lipid levels, the case-control difference was -0.05 mg per deciliter; -0.17 to 0.07). These data do not support hypotheses relating intake or serum levels of antioxidant vitamins to a reduced cancer risk.
维生素 A、E 和胡萝卜素：补充对其血浆水平的影响。
DOI：
10.1093/ajcn/38.4.559
发表时间：
1983
期刊：
The American journal of clinical nutrition
影响因子：
--
作者：
Willett,WC;Stampfer,MJ;Underwood,BA;Taylor,JO;Hennekens,CH
通讯作者：
Hennekens,CH