Histo-epidemiological profile of breast cancers among women in the Central African Republic: about 174 cases
Histo-epidemiological profile of breast cancers among women in the Central African Republic: about 174 cases
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DOI：
10.1186/s12885-018-4256-2
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发表时间：
2018-04-05
期刊：
影响因子：
3.8
通讯作者：
Koffi, Boniface
中科院分区：
文献类型：
--
作者：
Balekouzou, Augustin;Yin, Ping;Koffi, Boniface
背景：乳腺癌是世界范围内女性最常见的癌症，也是发展中国家癌症死亡的主要原因。中非共和国关于不列颠哥伦比亚的数据非常有限。本研究的目的是描述的流行病学和组织病理学特征的BC在Bangui.Methods：这项回顾性研究回顾了癌症数据登记处和医疗记录，从病理学单位的国家实验室在班吉和普通外科和妇科服务，从2003年至2015年。结果：共调查174例BC，年平均发病率为13.4例/年，平均发病率为13.4例/年。诊断时女性的年龄从16岁到90岁不等，中位数为45.5岁，四分位数间距（IQR）为18岁。45-54岁的年龄组代表了研究人群的大多数（n = 51，29.3%）。25.9%的患者未受过教育，85.6%的患者居住在城市。超过48%的妇女是家庭主妇，经济状况中等（n = 99，56.9%）。病理科收到的标本中有69%是乳腺肿瘤。浸润性导管癌（n = 113，64.9%）是主要的组织学形式，大多数肿瘤为III级（n = 14，46.7%）。唯一的影像学评估是在（n = 53，30.4%）女性中进行的超声检查。166例（95.4%）患者接受了手术治疗，159例（91.4%）患者接受了补充化疗。在研究结束时，84.5%的情况下死亡，12.1%活着，3.4%被认为是“失去后续行动”。结论：BC是一个重要的公共卫生问题，影响大多数年轻的中非妇女。流行病学和组织学特征或多或少与其他发展中国家所描述的特征相同。提高医疗机构和妇女对BC负担的认识，开展BC早期筛查，增强妇女医疗保健系统的能力势在必行。
Background: Breast cancer (BC) is the most common cancer in women worldwide and leading cause of cancer deaths indeveloping countries. There is very limited data on BC in the Central African Republic. The purpose of this study was to describe the epidemiological and histopathological characteristics of BC in Bangui.Methods: This retrospective study reviewed cancer data registries and medical records from the Pathology Unit of the National Laboratory in Bangui and the General Surgery and Gyneacology service from 2003 to 2015. A questionnaire was designed to collect information and data was analysed using descriptive and inferential statistical methods.Results: In total, 174 cases of BC were recorded, with an average annual frequency of13.4 cases per year. The age of the women at diagnosis varied from 16 to 90 years with a median of 45.5 years and InterQuartile range (IQR) 18 years. The age group of 45-54 years represented the majority of the study population (n = 51, 29.3%). About 25.9% ofthe patients were non-educated and 85.6% lived in cities. Over 48 % of the women were housewives with a moderate economic status (n = 99, 56.9%). Sixty nine percent of the specimens received at the pathology unit were pieces of breast tumour. Invasive ductal carcinoma (n = 113, 64.9%) was the main histological form and most of the tumours were of Grade III (n = 14, 46.7%). The only imaging assessment was ultrasound performed in (n = 53, 30.4%) women. Surgery was performed in (n = 166, 95.4%) patients, while (n = 159, 91.4%) received complementary chemotherapy. At the end of the study, 84.5% of the cases had died, 12.1% were alive and 3.4% were considered "lost to follow-up".Conclusion: BC is an important public health problem and affected most of the younger Central African women. Epidemiological and histological characteristics are more or less common to those described other developing countries. It is imperative to improve the awareness of health care institutions and women on the burden of BC, to carry out early screening of BC, and to strengthen the capacity of women's health care system.