S19159, a modulator of neurite outgrowth produced by the ascomycete Preussia aemulans -: I.: Producing strain, fermentation, isolation and biological activity
S19159, a modulator of neurite outgrowth produced by the ascomycete Preussia aemulans -: I.: Producing strain, fermentation, isolation and biological activity
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DOI：
10.7164/antibiotics.51.897
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发表时间：
1998-10-01
影响因子：
3.3
通讯作者：
Kitamoto, K
中科院分区：
文献类型：
--
作者：
Sato, T;Hanada, T;Kitamoto, K
从真菌菌种19159的发酵液中分离到一种神经突生长调节剂，命名为S19159。鉴定该真菌为房孢菌，Preussia aemulans (Rehm) von Arx。在S19159存在的情况下，大脑皮层神经元细胞体外伸出的神经突数量明显减少。S19159的作用在中枢神经系统的神经元中被观察到。该化合物对培养的皮层神经元、海马神经元和小脑神经元具有相似的活性，但对背根神经节神经元和PC12细胞无明显影响。
A modulator of neurite outgrowth, designated S19159, was isolated from the fermentation broth of fungal strain 19159. This fungus was identified as the loculoascomycete, Preussia aemulans (Rehm) von Arx. In the presence of S19159, the number of neurites extending from the cell bodies of cerebral cortical neurons was markedly reduced. The effect of S19159 was observed specifically in neurons from the central nervous system. The compound exhibited similar activities on cultured cortical, hippocampal and cerebeller neurons but was without detectable effect on dorsal root ganglion neurons and PC12 cells.