Epigenetic Regulation of Cardiac Neural Crest Cells.
Epigenetic Regulation of Cardiac Neural Crest Cells.
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心脏神经嵴细胞的表观遗传调控。
DOI：
10.3389/fcell.2021.678954
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发表时间：
2021
影响因子：
5.5
通讯作者：
Jiao K
中科院分区：
文献类型：
--
作者：
Yan S;Lu J;Jiao K
心脏神经嵴细胞（cNCCs）是一种短暂的、迁移的细胞群，有助于大动脉和心脏隔膜和瓣膜的形成。cncc的异常发育导致一系列主要影响心脏流出区的先天性心脏缺陷。信号分子和转录因子是研究最多的控制cNCC发育的调控事件。然而，近年来越来越多的证据支持表观遗传调控在cNCC的发育中也起着重要作用。本文就表观遗传调控因子在cNCC发育过程中的作用以及与cNCC相关的心血管缺陷进行综述。这些因子包括atp依赖性染色质重塑因子、组蛋白修饰因子和DNA甲基化调节剂。在许多情况下，已知编码这些因子的基因突变会导致先天性心脏病。更好地了解表观遗传调控因子及其在心脏发育过程中的作用，将最终有助于先天性心脏病患者新的临床应用的发展。
The cardiac neural crest cells (cNCCs) is a transient, migratory cell population that contribute to the formation of major arteries and the septa and valves of the heart. Abnormal development of cNCCs leads to a spectrum of congenital heart defects that mainly affect the outflow region of the hearts. Signaling molecules and transcription factors are the best studied regulatory events controlling cNCC development. In recent years, however, accumulated evidence supports that epigenetic regulation also plays an important role in cNCC development. Here, we summarize the functions of epigenetic regulators during cNCC development as well as cNCC related cardiovascular defects. These factors include ATP-dependent chromatin remodeling factors, histone modifiers and DNA methylation modulators. In many cases, mutations in the genes encoding these factors are known to cause inborn heart diseases. A better understanding of epigenetic regulators, their activities and their roles during heart development will ultimately contribute to the development of new clinical applications for patients with congenital heart disease.
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影响因子：
2.7
作者：
Chandler RL;Magnuson T
通讯作者：
Magnuson T
影响因子：
3.5
作者：
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通讯作者：
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2.6
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通讯作者：
Krebs, Jocelyn E.
影响因子：
64.8
作者：
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