Clonal and temporal patterns of nasopharyngeal penicillin-susceptible and penicillin-resistant Streptococcus pneumoniae stains in children attending a day care center
Clonal and temporal patterns of nasopharyngeal penicillin-susceptible and penicillin-resistant Streptococcus pneumoniae stains in children attending a day care center
复制标题
日托中心儿童鼻咽青霉素敏感和青霉素耐药肺炎链球菌染色的克隆和时间模式
DOI：
--
复制
发表时间：
1996
影响因子：
9.4
通讯作者：
Jean
中科院分区：
文献类型：
--
作者：
Jean;MARIE;Emmanuelle Martin;Carine Lemort;Michèle Nouvellon;Eric Mallet;Jean
在1993年至1994年冬季的11月、1月和3月的三个观察期内，分析了116名参加法国鲁昂日托中心的儿童的青霉素敏感和青霉素耐药肺炎链球菌（分别为PSSp和PRSp）的鼻咽携带情况。S.在每个不同的观察期，发现肺炎球菌分别为47.7%、47.3%和49.6%，PRSP分别占肺炎球菌分离株的42.2%、40.3%和40.6%。在11月回收的52株分布在34个电泳型（ESTA）的多位点酶电泳; 15个PRSP分离株，血清型23 F，属于一个克隆复合体的5个ESTA，代表PRSP在11月的优势种群。S.通过对17名儿童的分离株进行多位点酶分析，研究了他们在三个时期的肺炎携带情况。PSSp分离，表现出明显的优势，是短暂的，只有在这些日托出席者。相比之下，大多数的PRSp分离在1月和3月属于克隆复合体。因此，该PRSp人群在整个研究期间都居住在日托中心。
The nasopharyngeal carriage of penicillin-susceptible and penicillin-resistant Streptococcus pneumoniae (PSSp and PRSp, respectively) was analyzed in 116 children attending a day care center in Rouen, France, by three observation periods in November, January, and March of the winter of 1993 to 1994. The carriage rate of S. pneumoniae was found to be 47.7, 47.3, and 49.6% at each different observation period, and PRSp accounted for 42.2, 40.3, and 40.6% of pneumococcal isolates, respectively. The 52 isolates recovered in November were distributed in 34 electrophoretic types (ETs) by multilocus enzyme electrophoresis; 15 PRSp isolates, all of serotype 23F, belonged to a clonal complex of five ETs, representing the dominant population of PRSp in November. The temporal pattern of S. pneumoniae carriage was studied in 17 children who were colonized at the three periods by multilocus enzyme analysis of their isolates. The PSSp isolated, exhibiting distinct ETs, were transient only among these day care attendees. In contrast, most of the PRSp isolated in January and March belonged to the clonal complex. Thus, this PRSp population was resident in the day care center throughout the study period.