Consumptive reduction following increased production of CD34-posistive cells and carotid intima-media thickness in non-hypertensive elderly Japanese men.
Consumptive reduction following increased production of CD34-posistive cells and carotid intima-media thickness in non-hypertensive elderly Japanese men.
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在非高血压老年日本男性中，随着 CD34 阳性细胞的产生和颈动脉内膜中层厚度增加，消耗减少。
DOI：
10.1080/2331205x.2019.1629169
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Maeda T
中科院分区：
文献类型：
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作者：
Shimizu Y;Yamanashi H;Noguchi Y;Koyamatsu J;Kiyoura K;Kawashiri SY;Maeda T
背景：循环中CD34阳性细胞数量的增加已被证明对动脉粥样硬化有保护作用，因为与疾病呈负相关。然而，据报道，动脉粥样硬化的参与者也有造血活性增加的报道。方法：对335名60~69岁的非高血压老年男性进行横断面研究。结果：在非超重者中，CD34阳性细胞计数与颈动脉内膜中层厚度无相关性(经自然对数转化的CD34阳性细胞与颈动脉内中膜厚度的调整标准化参数估计(β)为β=−0.03，p=0.630)，超重者CD34阳性细胞计数与CIMT呈显著负相关(β=−=0.029)。由于超重受试者的CD34阳性细胞水平明显高于非超重受试者(p=0.005)，我们通过对CD34阳性细胞水平进行分层来进一步分析结果。结果显示，CD34阳性细胞计数与CIMT之间的显著相关性仅限于CD34阳性细胞计数高的受试者(CD34阳性细胞计数低的受试者CD34阳性细胞计数的β=−为0.09，p=0.242；CD34阳性细胞计数高的受试者CD34阳性细胞计数的β=−为0.22，p=0.007)。结论：CD34阳性细胞计数与CIMT之间的负相关性仅限于超重受试者和CD34阳性细胞计数高的个体。
Background: Increase in the number of circulating CD34-positive cells has been shown to have a protective effect against atherosclerosis, owing to an inverse association with the disease. However, increased hematopoietic activity is also reported in atherosclerotic participants. Thus, this study investigated the association between circulating CD34-positive cells and carotid intima-media thickness (CIMT) in elderly men.Methods: We conducted a cross-sectional study in 335 non-hypertensive elderly men (aged 60–69 years), as hypertension masks the beneficial effects of circulating CD34-positive cells.Results: In case of non-overweight subjects, no association was found between the CD34-positive cell count and CIMT (adjusted-standardized parameter estimate (β) between natural log-transformed CD34-positive cells and CIMT was β = −0.03,p= 0.630), while a significant inverse correlation was observed between CD34-positive cell count and CIMT in case of overweight subjects (β = −0.26,p= 0.029). As overweight subjects had significantly higher levels of CD34-positive cells than non-overweight subjects (p= 0.005), we analyzed the results further by stratifying the levels of CD34-positive cells. Results showed that the significant association between the CD34-positive cell count and CIMT is limited to subjects with a high CD34-positive cell count (β = −0.09,p= 0.242 for subjects with low CD34-positive cell count; and β = −0.22,p= 0.007 for subjects with a high CD34-positive cell count).Conclusion: The inverse correlation between CD34-positive cells and CIMT was limited to overweight subjects and individuals with a high CD34-positive cell count as a result of endothelial injury that stimulates CD34-positive cell production.