The role of long non-coding RNAs in nasopharyngeal carcinoma: As systemic review.
The role of long non-coding RNAs in nasopharyngeal carcinoma: As systemic review.
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长链非编码RNA在鼻咽癌中的作用：系统评价
DOI：
10.18632/oncotarget.14211
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发表时间：
2017-02-28
期刊：
影响因子：
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通讯作者：
Luo DX
中科院分区：
文献类型：
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作者：
He R;Hu Z;Wang Q;Luo W;Li J;Duan L;Zhu YS;Luo DX
近年来的研究发现，长链非编码RNA（lncRNA）在肿瘤的发生、发展中起着重要作用。在东南亚和北非，鼻咽癌（NPC）是最常见的侵袭性鳞状细胞癌。鼻咽癌最常见于男性。然而，鼻咽癌是由病毒、环境因素和遗传等多种因素共同引起的。到目前为止，NPC的潜在途径或机制尚不清楚。本文着重介绍了长链非编码RNA（lncRNA）及其在鼻咽癌中的重要作用。研究表明，lncRNA调节不同类型癌症（包括NPC）的发生和进展。此外，已发现染色质组织、转录和转录后事件受lncRNA调控。本文综述了lncRNA在鼻咽癌中的作用，并对lncRNA在鼻咽癌诊断、预后判断和治疗中的可行性进行了综述。
Recent development of cutting edge research found that long noncoding RNAs (lncRNAs) plays important roles in carcinogenesis and progression. In Southeast Asia and North Africa, nasopharyngeal carcinoma (NPC) is the most common aggressive squamous cell carcinoma. Nasopharyngeal carcinoma is most frequently occurring in males. However, nasopharyngeal carcinoma is caused by a combination of several factors as viral, environmental factors, and heredity. Till now, the potential pathway or mechanism of NPC is not well known. In our present review, we strongly emphasized on long noncoding RNAs (lncRNAs) and its significant role in nasopharyngeal carcinoma. It has been showed that lncRNAs regulate the development and progression of different types of cancers, including NPC. In addition, it has been found that chromatin organization, transcriptional and post-transcriptional events are regulated by lncRNAs. Our present review summarizes the roles of lncRNAs in nasopharyngeal carcinoma and provides an overview of the feasibility of lncRNAs as diagnosis, prognosis and potential treatment for NPC patients.