A practical ruthenium-catalyzed cleavage of the allyl protecting group in amides, lactams, imides, and congeners
A practical ruthenium-catalyzed cleavage of the allyl protecting group in amides, lactams, imides, and congeners
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DOI：
10.1002/chem.200501227
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发表时间：
2006-03-20
影响因子：
4.3
通讯作者：
Alonso, JM
中科院分区：
文献类型：
--
作者：
Alcaide, B;Almendros, P;Alonso, JM
提出了一种简便的n -烯丙基酰胺类基团脱保护方法。钌催化的酰胺类、内酰胺类、亚胺类、吡唑烷酮类、酰脲类和恶唑烷酮类脱烯化反应的第一个例子是通过依次使用Grubbs卡宾（异构化步骤）和RUCl3（氧化步骤）实现的。可以使用多种底物，包括对映体纯多功能β -内酰胺和γ -内酰胺。
A convenient methodology for the deprotection of N-allylic amide-like moieties was developed. The first examples accounting for the ruthenium-catalyzed deallylation of amides, lactams, imides, pyrazolidones, hydantoins, and oxazolidinones have been achieved by the sequential use of Grubbs carbene (isomerization step) and RUCl3 (oxidation step). A variety of substrates, including enantio-pure multifunctional beta- and gamma-lactams, can be employed.