Single nucleotide polymorphisms, haplotype association and tumour expression of the vascular endothelial growth factor (VEGF) gene with lung carcinoma
Single nucleotide polymorphisms, haplotype association and tumour expression of the vascular endothelial growth factor (VEGF) gene with lung carcinoma
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DOI：
10.1016/j.gene.2017.01.007
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发表时间：
2017-04-15
期刊：
影响因子：
3.5
通讯作者：
Shah, Zafar A.
中科院分区：
文献类型：
--
作者：
Naykoo, Niyaz A.;Dil-Afroze;Shah, Zafar A.
VEGF包含几个已知影响其表达的多态性位点。我们检查了199个克什米尔人患者和401个健康对照组中 + 405（-634）C> g， + 936c> t，-2578c> a和肺癌之间的可能关联。与VEGF + 405cc， + 936cc和-2578AA + CC基因型相比，VEGF + 405CG，936CT + TT和-2578CA基因型与肺癌风险显着相关，并与肺癌的风险相关。 0.13），p <0.0001]。单倍型分析表明，VEGF基因的CGA和TGA单倍型传达了肺癌的风险[OR = 0.18（0.10-0.33），P <0.0001和0.07（0.03-0.13），P <0.0001]。 VEGF表达揭示了与三个SNP的基因型无关紧要的关联。总之，所检查的SNP似乎会影响肺癌的敏感性，而随着SNP的基因型似乎与肺部肿瘤中的VEGF mRNA表达没有显着关联。 （c）2017 Elsevier B.V.保留所有权利。
VEGF contains several polymorphic sites known to influence its expression. We examined the possible association between + 405(-634)C > G, + 936C > T, - 2578C > A and lung cancer in 199 Kashmiri patients and 401 healthy controls. VEGF + 405CG, 936CT + TT and - 2578CA genotypes were significantly associated with lung cancer risk compared to VEGF + 405CC, + 936CC and - 2578AA + CC genotypes [OR = 0.07 (0.04 - 0.13), P < 0.0001, OR = 036 (0.25 - 0.52), P < 0.0001 and 0.08 (0.05 - 0.13), P < 0.0001]. Haplotype analysis revealed that CGA and TGA haplotypes of VEGF gene conveys the risk for lung cancer [OR = 0.18 (0.10 - 0.33), P < 0.0001 and 0.07 (0.03 - 0.13), P < 0.0001]. VEGF expression revealed non-significant association with the genotypes of the three SNPs. In conclusion, the SNPs examined appear to influence lung cancer susceptibility while as genotypes of the SNPs don't appear to have significant association with VEGF mRNA expression in lung tumours. (C) 2017 Elsevier B.V. All rights reserved.