Anti-heat shock protein 90η antibodies are detected in patients with multiple sclerosis during remission
Anti-heat shock protein 90η antibodies are detected in patients with multiple sclerosis during remission
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DOI：
10.1016/j.jneuroim.2006.11.001
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发表时间：
2007-03-01
影响因子：
3.3
通讯作者：
Alcazar, A.
中科院分区：
文献类型：
--
作者：
Cid, C.;Regidor, I.;Alcazar, A.
抗热休克蛋白 90 β (Hsp90 β) 的抗体可识别少突胶质细胞前体细胞表面的抗原，并诱导细胞培养物中少突胶质细胞群的减少。本研究调查了多发性硬化症 (MS) 患者缓解期间抗 Hsp90 β 抗体的存在情况。使用来自细胞膜组分的 Hsp90 beta，通过特异性且灵敏的蛋白质印迹程序在患者的脑脊液 (CSF) 中检测到抗 Hsp90 beta 抗体。在 MS 患者中，脑脊液中检测到的抗 Hsp90 β 抗体的患者数量明显多于患有其他神经系统疾病的对照患者（其中包括患有其他炎症性神经系统疾病的患者）。 MS 患者的 CSF 抗 Hsp90 β 抗体水平显着高于对照患者。 MS 患者缓解期间脑脊液中存在抗 Hsp90 β 抗体，可能表明这些自身抗体在 MS 中具有潜在的致病作用。 (c) 2006 Elsevier B.V. 保留所有权利。
Antibodies against heat shock protein 90 beta (Hsp90 beta) recognize the antigen on the surface of oligodendrocyte precursor cells and induce a decrease in the oligodendrocyte population of cell cultures. This study investigated the presence of anti-Hsp90 beta antibodies in patients with multiple sclerosis (MS) during remission. Anti-Hsp90 beta antibodies were detected in the cerebrospinal fluid (CSF) of patients with a specific and sensitive western blot procedure using Hsp90 beta from cell membrane fraction. The number of patients with anti-Hsp90 beta antibodies detected in the CSF was significantly greater in MS patients than in control patients with other neurological diseases, which included patients with other inflammatory neurological diseases. CSF anti-Hsp90 beta antibody levels were significantly higher in MS patients than in control patients. The presence of anti-Hsp90 beta antibodies in the CSF of MS patients during remission could suggest a potential pathogenic role for these autoantibodies in MS. (c) 2006 Elsevier B.V. All rights reserved.