Excretion of phenol red and its glucuronide in the dogfish shark.
Excretion of phenol red and its glucuronide in the dogfish shark.
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DOI：
10.3109/00498257609151606
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发表时间：
1976
期刊：
影响因子：
--
通讯作者：
A. Guarino;J. Anderson
中科院分区：
文献类型：
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作者：
A. Guarino;J. Anderson
1.在完整的动物和胆瘘动物中，测量了角鲨（Squalus acanthias）的酚红及其葡萄糖醛酸苷的胆汁和尿液排泄。2.酚红被角鲨广泛代谢为葡萄糖醛酸苷，两种形式的化合物都被主动转运到胆汁和尿液中。3.两种化合物均以较大的浓度梯度从血浆转移至尿液和胆汁;转移过程在肾室和肝室中最容易饱和;游离药物和葡糖苷酸的两种排泄途径均受到丙磺舒的抑制。4.总（游离+葡糖苷酸）酚红的48小时胆汁排泄无显著差异，但尿液或完整鱼中的总药物含量是瘘管动物的2倍。
1. The biliary and urinary excretion of phenol red and its glucuronide was measured in dogfish sharks, Squalus acanthias, in both intact animals and animals with biliary fistula. 2. Phenol red is extensively metabolized to its glucuronide by the dogfish shark and both forms of the compound are actively transported into bile and urine. 3. Both compounds are transferred from plasma to urine and bile against a large concentration gradient; the transfer process is saturable most easily in the renal compartment but also in the hepatic compartment; and both excretion routes for the free drug and the glucuronide are inhibited by probenecid. 4. There were no significant differences in the 48 h biliary excretion of total (free + glucuronide) phenol red, but the urine or intact fish contained two-fold more total drug than did animals with fistulae.