ISOLATION AND CHARACTERIZATION OF THE MINOR COMPONENTS ASSOCIATED WITH MICROCYSTINS LR AND RR IN THE CYANOBACTERIUM (BLUE-GREEN-ALGAE)
ISOLATION AND CHARACTERIZATION OF THE MINOR COMPONENTS ASSOCIATED WITH MICROCYSTINS LR AND RR IN THE CYANOBACTERIUM (BLUE-GREEN-ALGAE)
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DOI：
10.1016/0041-0101(90)90006-s
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发表时间：
1990-01-01
期刊：
影响因子：
2.8
通讯作者：
CARMICHAEL, WW
中科院分区：
文献类型：
--
作者：
HARADA, K;MATSUURA, K;CARMICHAEL, WW
利用层析方法分离得到两种结构相似的微囊藻毒素LR和RR类似物，即微囊藻环肽肝毒素。虽然它们有相同的分子量。野生型和氨基酸组成与母体毒素不同，它们不具有相似的毒性。两种组分的紫外和1H-NMR光谱数据表明，这些环肽与母体毒素存在明显的结构差异，这可能是其观察到的毒性显著降低的原因。
Two structurally similar analogues of microcystins LR and RR, cyclic peptide hepatotoxins from Microcystis, were isolated by chromatographic methods. Although they have the same mol. wt and amino acid compositions as those of the parent toxins, they do not possess similar toxicities. Ultraviolet and 1H-NMR spectral data for both components demonstrate clear structural difference of these cyclic peptides from the parent toxins, which are probably responsible for the marked decreases in their observed toxicities.