Irciniasulfonic acid B, a novel taurine conjugated fatty acid derivative from a Japanese marine sponge, Ircinia sp.
Irciniasulfonic acid B, a novel taurine conjugated fatty acid derivative from a Japanese marine sponge, Ircinia sp.
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DOI：
10.1016/j.tet.2006.03.087
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发表时间：
2006-06-12
期刊：
影响因子：
2.1
通讯作者：
Miyamoto, Tomofumi
中科院分区：
文献类型：
--
作者：
Emura, Chisato;Higuchi, Ryuichi;Miyamoto, Tomofumi
Irciniasulfate acid B（1）是从海绵Irciniasp.中提取的，以及已知的多药耐药性调节剂Irciniasulfenic acid（2）。光谱和化学分析表明，结构由常见的不饱和脂肪酸，一种新的不饱和支链脂肪酸，和牛磺酸。最终实现了Irciniasulfate酸B（1）与其甲基化衍生物的分离。Irciniasulfate acid B（1）逆转多药耐药的作用与Irciniasulfate acid相同。(c)2006爱思唯尔有限公司保留所有权利。
Irciniasulfonic acid B (1) was obtained from a marine sponge, Ircinia sp., together with a known multi-drug resistance modulator irciniasulfonic acid (2). Spectroscopic and chemical analyses revealed structure consisting of common unsaturated fatty acids, a novel unsaturated branched fatty acid, and a taurine. Final separation of irciniasulfonic acid B (1) was achieved with its methylated derivatives. Irciniasulfonic acid B (1) reversed the multi-drug resistance in the same way as irciniasulfonic acid. (c) 2006 Elsevier Ltd. All rights reserved.