Ligand-induced polymerization.
Ligand-induced polymerization.
复制标题
配体诱导聚合。
作者：
L. W. Nichol;D. Winzor
配体诱导聚合的三种模型被认为是，包括受体-配体复合物的二聚化和交联的单体单元通过配体桥形成二聚体或线性链。对于每个模型的结合方程的开发和检查的限制，形式，和交叉的一个家庭的曲线，每个成员构造固定的，但不同的总受体浓度。出现的结合曲线的特征与通过检查受体组分的重均分子量或其函数对配体浓度的依赖性而发现的特征相关。在后一图中，在相应结合曲线相交的相同配体浓度下，交联模型存在最大值：最大值的存在意味着在配体的饱和浓度下仅保留单体受体成分。这些研究结果的实际意义进行了讨论的实验系统以前在文献中报道。此外，特别评论的形式上的约束曲线的三个模型，假设形状通常与积极和消极的协同性。最后，比较与那些系统中，其中向聚合物成分的转移是由预先存在的关联平衡的配体扰动的影响。
Three models of ligand-induced polymerization are considered, encompassing dimerization of acceptor-ligand complex and cross-linking of monomer units via a ligand bridge to form either dimer or linear chains. For each model a binding equation is developed and examined in terms of limits, form, and intersection within a family of curves, each member constructed with fixed but different total acceptor concentration. The characteristics of the binding curves that emerge are correlated with those found by examining the dependence on ligand concentration of either the weight-average molecular weight of the acceptor constituent or a function of it. In the latter plots, a maximum exists for the cross-linking models at the same ligand concentration that the corresponding binding curves intersect: the existence of the maximum implies that at saturating concentrations of ligand only monomeric acceptor constituent remains. The practical implication of these findings is discussed in terms of experimental systems reported previously in the literature. In addition, particular comment is made on the forms of binding curves for the three models, which assume shapes generally associated with positive and negative cooperativity. Finally, comparison is made with those systems in which a shift toward polymeric constituent is effected by ligand perturbation of a preexisting association equilibrium.