DRD4 and striatal modulation of the link between childhood behavioral inhibition and adolescent anxiety.
DRD4 and striatal modulation of the link between childhood behavioral inhibition and adolescent anxiety.
复制标题
DRD4 和纹状体调节儿童行为抑制和青少年焦虑之间的联系。
DOI：
10.1093/scan/nst001
复制
发表时间：
2014
影响因子：
4.2
通讯作者：
Ernst,Monique
中科院分区：
文献类型：
--
作者：
Pérez-Edgar,Koraly;Hardee,JillianE;Guyer,AmandaE;Benson,BrendaE;Nelson,EricE;Gorodetsky,Elena;Goldman,David;Fox,NathanA;Pine,DanielS;Ernst,Monique
Behavioral inhibition (BI), a temperament characterized by vigilance to novelty, sensitivity to approach–withdrawal cues and social reticence in childhood, is associated with risk for anxiety in adolescence. Independent studies link reward hyper-responsivity to BI, adolescent anxiety and dopamine gene variants. This exploratory study extends these observations by examining the impact ofDRD4genotype and reward hyper-responsivity on the BI–anxiety link. Adolescents (N= 78) completed a monetary incentive delay task in the fMRI environment. Participants were characterized based on a continuous score of BI and the 7-repeat allele (7R+) of theDRD4functional polymorphism. Parent-report and self-report measures of anxiety were also collected. Across the entire sample, striatal activation increased systematically with increases in the magnitude of anticipated monetary gains and losses.DRD4status moderated the relation between BI and activation in the caudate nucleus. Childhood BI was associated with parent report of adolescent anxiety among 7R+ participants with elevated levels of striatal response to incentive cues.DRD4genotype influenced the relations among neural response to incentives, early childhood BI and anxiety. The findings help refine our understanding of the role reward-related brain systems play in the emergence of anxiety in temperamentally at-risk individuals, building a foundation for future larger scale studies.
