IDENTIFICATION OF AMYLOID-BETA PROTEIN IN THE BRAIN OF THE SMALL, SHORT-LIVED LEMURIAN PRIMATE MICROCEBUS-MURINUS
IDENTIFICATION OF AMYLOID-BETA PROTEIN IN THE BRAIN OF THE SMALL, SHORT-LIVED LEMURIAN PRIMATE MICROCEBUS-MURINUS
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DOI：
10.1016/0197-4580(94)90115-5
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发表时间：
1994-03-01
影响因子：
4.2
通讯作者：
SELKOE, D
中科院分区：
文献类型：
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作者：
BONS, N;MESTRE, N;SELKOE, D
在小型利莫里亚灵长类动物Microcebus murinus中，淀粉样β（A β）蛋白在脑中的沉积已被免疫细胞化学证实。脑膜脑血管沉积物和皮质实质沉积物均发生。所有八个年龄（> 8岁）的Microcebus检查显示血管淀粉样蛋白沉积，而只有四个表现出实质斑块。血管淀粉样蛋白浸润软脑膜和皮质动脉和小动脉的图尼卡中膜，也见于毛细血管。观察到β沉积在皮质神经元中的三种一般形式：圆形或椭圆形斑块，呈硫黄素阴性，但有时显示A β免疫反应性的中心浓度;圆形斑块，具有密集的免疫反应性核心，呈硫黄素阳性;广泛的带状浸润，包围多个皮质血管。这些观察结果与先前对Microcebus中与年龄相关的神经退行性变化的描述一起表明，该物种经历了与阿尔茨海默病中所见高度相似的β-淀粉样蛋白相关神经病理学。我们的结论是，这种狐猴灵长类动物的小尺寸和相对较短的预期寿命，提供了一个令人信服的动物模型的一些主要特征的阿尔茨海默氏病。
The deposition of amyloid beta (A beta) protein in the brain has been demonstrated immunocytochemically in the small Lemurian primate Microcebus murinus. Both meningocerebral vascular deposits and cortical parenchymal deposits occur. All eight aged (> 8 years old) Microcebus examined showed vascular amyloid deposits, whereas only four exhibited parenchymal plaques. The vascular amyloid infiltrated the tunica media of the leptomeningeal and cortical arteries and arterioles and was also found in capillaries. A beta was observed to be deposited in three general forms in the cortical neuropil: round or elliptical plaques that were thioflavin-negative but sometimes showed a central concentration of A beta immunoreactivity; round plaques with a densely immunoreactive core that was thioflavin-positive; extensive ribbon-like infiltrations enclosing multiple cortical blood vessels. These observations, taken together with previous descriptions of age-related neurodegenerative changes in Microcebus, indicate that this species undergoes a beta-amyloid-associated neuropathology highly similar to that seen in Alzheimer's disease. We conclude that this lemurian primate of small size and relatively short life expectancy, provides a compelling animal model of some principal features of Alzheimer's disease.