Gestational age and birth growth parameters as early predictors of fetal alcohol spectrum disorders.
Gestational age and birth growth parameters as early predictors of fetal alcohol spectrum disorders.
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DOI：
10.1111/acer.14656
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发表时间：
2021-08
期刊：
影响因子：
--
通讯作者：
May PA
中科院分区：
文献类型：
--
作者：
Hasken JM;Marais AS;de Vries M;Joubert B;Cloete M;Botha I;Symington SR;Kalberg WO;Buckley D;Robinson LK;Manning MA;Parry CDH;Seedat S;Hoyme HE;May PA
调查胎龄和出生时生长作为胎儿酒精谱系障碍（FASD）的预测因子。这里分析的样本代表了737名随机选择的儿童，他们在7岁时进行了生长，畸形和神经行为评估。母亲进行访谈，以确定产前酒精暴露和其他产妇的危险因素。出生数据来自诊所记录，7岁时的数据来自基于人口的在校研究。二元线性回归评估了早产、小于胎龄儿（SGA）及其组合与特定FASD诊断或任何FASD的几率之间的关系。在7岁时被诊断为FASD的儿童中，出生记录显示18.4%为早产，51.4%为SGA，5.9%为早产和SGA。相比之下，非FASD对照组的出生率分别为：12.0%、27.7%和0.5%。患有FASD儿童的母亲报告在所有三个月期间饮酒更多，妊娠率更高，教育程度更低，怀孕年龄更大。在控制了孕早期每天饮酒量、孕中期饮酒次数、母亲受教育程度、烟草使用和母亲年龄后，7岁时FASD诊断的优势比与SGA显著相关（OR=2.16，95%CI：1.35-3.45）。SGA还与FASD连续体中三种最常见的特定诊断中的每一种显著相关：胎儿酒精综合征（FAS）（OR=3.1），部分FAS（PFAS）（OR=2.1）和酒精相关神经发育障碍（ARND）（OR=2.0）。SGA是一个强大的早期指标FASD在这个随机抽样的儿童在7岁时进行评估。
Investigate gestational age and growth at birth as predictors of fetal alcohol spectrum disorders (FASD). The sample analyzed here represents 737 randomly-selected children who were assessed for growth, dysmorphology, and neurobehavior at seven years of age. Maternal interviews were conducted to ascertain prenatal alcohol exposure and other maternal risk factors. Birth data originated from clinic records, and the data at seven years of age originated from population-based, in-school studies. Binary linear regression assessed the relationship between preterm birth, small-for-gestational age (SGA), and their combination on the odds of a specific FASD diagnosis or any FASD. Among children diagnosed with FASD at seven years of age, review of birth records indicated 18.4% were born preterm, 51.4% were SGA, and 5.9% were both preterm and SGA. This compares to not-FASD controls whose birth percentages were respectively: 12.0%, 27.7%, and 0.5%. Mothers of children with FASD reported more drinking during all trimesters, higher gravidity, lower educational attainment, and older age at pregnancy. After controlling for usual drinks per drinking day in 1st trimester, number of trimesters drank, maternal education, tobacco use, and maternal age, the odds ratio of an FASD diagnosis by age seven was significantly associated with SGA (OR=2.16, 95%CI:1.35–3.45). SGA was also significantly associated with each of the three most common specific diagnoses within the FASD continuum: fetal alcohol syndrome (FAS) (OR=3.1), partial FAS (PFAS) (OR=2.1), and alcohol-related neurodevelopmental disorder (ARND) (OR=2.0). SGA is a robust early indicator for FASD in this random sample of children assessed at seven years of age.
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影响因子：
2.4
作者：
Fenton TR;Kim JH
通讯作者：
Kim JH
DOI：
10.3390/ijerph14050522
发表时间：
2017-05-12
影响因子：
--
作者：
May PA;De Vries MM;Marais AS;Kalberg WO;Buckley D;Adnams CM;Hasken JM;Tabachnick B;Robinson LK;Manning MA;Bezuidenhout H;Adam MP;Jones KL;Seedat S;Parry CDH;Hoyme HE
通讯作者：
Hoyme HE
影响因子：
8
作者：
Hoyme, H. Eugene;Kalberg, Wendy O.;May, Philip A.
通讯作者：
May, Philip A.
影响因子：
8
作者：
Carter, R. Colin;Jacobson, Joseph L.;Jacobson, Sandra W.
通讯作者：
Jacobson, Sandra W.
影响因子：
4.2
作者：
May, Philip A.;de Vries, Marlene M.;Hoyme, H. Eugene
通讯作者：
Hoyme, H. Eugene