The photoinduced cleavage of coumarin dimers studied with femtosecond and nanosecond two-photon excitation
The photoinduced cleavage of coumarin dimers studied with femtosecond and nanosecond two-photon excitation
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DOI：
10.1016/j.cplett.2007.03.076
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发表时间：
2007-05-11
影响因子：
2.8
通讯作者：
Motzkus, M.
中科院分区：
文献类型：
--
作者：
Buckup, T.;Dorn, J.;Motzkus, M.
香豆素衍生物二聚体的光裂解是一种很有前途的激光控制药物释放机制。我们研究了双光子激发后，这样的反应的效率，比较飞秒和纳秒脉冲的范围从400到800 nm。对于较短的波长，光裂解反应明显更有效。双光子吸收（TPA）光谱的光谱轮廓类似于单光子吸收（SPA）光谱。还观察到，在相同的波长和光束面积下，用飞秒脉冲触发的光裂解反应比用纳秒脉冲触发的反应效率高约4.9 × 10（4）倍。(C)2007 Elsevier B.V.保留所有权利。
The photocleavage of a coumarin derivative dimer is a promising mechanism for laser controlled drug release in medical applications. We studied the efficiency of such reaction after two-photon excitation, comparing femtosecond and nanosecond pulses in the range from 400 to 800 nm. The photocleavage reaction is remarkably more efficient for shorter wavelengths. The spectral profile of the two-photon absorption (TPA) spectrum resembles the single-photon absorption (SPA) spectrum. It was also observed that the photocleavage reaction triggered with femtosecond pulses is about 4.9 x 10(4) times more efficient than the reaction with nanosecond pulses at the same wavelength and beam area. (C) 2007 Elsevier B.V. All rights reserved.