Hydrogel Microcapsules with a Thin Oil Layer: Smart Triggered Release via Diverse Stimuli
Hydrogel Microcapsules with a Thin Oil Layer: Smart Triggered Release via Diverse Stimuli
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DOI：
10.1002/adfm.202009553
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发表时间：
2020-12-18
影响因子：
19
通讯作者：
Choi, Chang-Hyung
中科院分区：
文献类型：
--
作者：
Jeong, Hye-Seon;Kim, Eunseo;Choi, Chang-Hyung
提出了一种具有中间薄油层的水凝胶微胶囊，可实现通过不同刺激触发的多种货物的智能释放。微流体技术用于生产具有薄油层的三重乳液液滴，该薄油层将最内层的水相与水凝胶预聚物相分开，水凝胶预聚物相通过光聚合转化为水凝胶壳。水凝胶微胶囊内的中间油层充当有效的扩散屏障，允许将各种小货物封装在多孔水凝胶壳内，直到施加刺激使油层不稳定。事实证明，可以利用包括化学溶解、机械应力和渗透压在内的多种刺激来按需释放封装的货物。此外，渗透压和水凝胶壳厚度可以独立调节，以控制释放的起始时间以及多货物封装的水凝胶微胶囊的释放行为。释放可以是同时的或选择性的。
A hydrogel microcapsule with an intermediate thin oil layer is presented to achieve smart release of a broad range of cargoes triggered via diverse stimuli. A microfluidic technique is used to produce triple emulsion droplets with a thin oil layer that separates the innermost aqueous phase from the hydrogel prepolymer phase, which transforms into a hydrogel shell via photopolymerization. The intermediate oil layer within the hydrogel microcapsule acts as an effective diffusion barrier, allowing encapsulation of various small cargoes within a porous hydrogel shell until a stimulus is applied to destabilize the oil layer. It is demonstrated that diverse stimuli including chemical dissolution, mechanical stress, and osmotic pressure can be utilized to release the encapsulated cargo on-demand. In addition, osmotic pressure and the hydrogel shell thickness can be independently tuned to control the onset time of release as well as the release behavior of multi-cargo encapsulated hydrogel microcapsule. The release can be either simultaneous or selective.