LEUKO-ARAIOSIS ON MAGNETIC-RESONANCE-IMAGING AND SPEED OF MENTAL PROCESSING
LEUKO-ARAIOSIS ON MAGNETIC-RESONANCE-IMAGING AND SPEED OF MENTAL PROCESSING
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DOI：
10.1001/archneur.1990.00530020047013
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发表时间：
1990-02-01
影响因子：
--
通讯作者：
MARTIVILALTA, JL
中科院分区：
文献类型：
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作者：
JUNQUE, C;PUJOL, J;MARTIVILALTA, JL
脑成像研究中发现的白色异常（称为脑白质疏松症（LA））的临床意义仍然不确定。尽管对LA可能导致的认知功能知之甚少，但脑白质疏松症与认知能力的全面下降有关。我们在41例有血管危险因素的老年患者中选择了一个样本，展示了磁共振成像显示的左心房严重程度与精神恶化之间的相关性。我们发现，LA与测量信息处理速度的任务的性能有关，特别是涉及复杂过程的任务。这种损害在日常生活活动减少方面可能很重要，因为它支持一些常用的行为评定量表发现的关系。白质疏松症也与一些原始反射的存在有关，这表明它们的去抑制可能是由于弥漫性离皮质纤维损伤。
The clinical significance of white matter abnormalities seen in brain imaging studies, termed leuko-araiosis (LA), still remains uncertain. Leuko-araiosis has been associated with a global decline in cognitive performance, although little is known about the cognitive functions that LA may account for. We present the correlates between LA severity on magnetic resonance imaging and mental deterioration in a selected sample of 41 elderly patients with vascular risk factors. We found that LA was related to performance on tasks measuring the speed of information processing and, in particular, on those that involve complex processes. This impairment can be important in producing reduction in daily living activities as it is in the support to the relationship found with some commonly used behavioral rating scales. Leuko-araiosis is also related to the presence of some primitive reflexes, suggesting that their disinhibition may be due to diffuse corticofugal fibers damage.