Dietary risk factors for invasive and in-situ cervical carcinomas in Bangkok, Thailand.
Dietary risk factors for invasive and in-situ cervical carcinomas in Bangkok, Thailand.
复制标题
泰国曼谷侵袭性和原位宫颈癌的饮食危险因素。
DOI：
10.1023/a:1020289618161
复制
发表时间：
2002
期刊：
影响因子：
--
通讯作者：
Kuypers,Jane
中科院分区：
文献类型：
--
作者：
Shannon,Jackilen;Thomas,DavidB;Ray,RobertaM;Kestin,Mark;Koetsawang,Amorn;Koetsawang,Suporn;Chitnarong,Kamolthip;Kiviat,Nancy;Kuypers,Jane
OBJECTIVE: Although human papillomavirus (HPV) may be a necessary cause of cervical cancer, most women with HPV infections do not develop this disease. This study was conducted to evaluate the possible effects of specific dietary factors on cervical carcinogenesis.METHODS: Fifty hospitalizedin-situcases and 125 controls were identified from family planning or gynecologic clinics associated with Siriraj hospital in Bangkok, Thailand, and 134 hospitalized invasive cases and 384 hospitalized controls from the public wards of Siriraj Hospital were administered a food-frequency questionnaire and tested for HPV DNA in exfoliated cervical cells. Odds ratios in relation to intake of foods high in vitamin C, folate, vitamin E, vitamin A, β-carotene, retinol, and cruciferous vegetables were estimated using logistic regression in case–control comparisons and in case–case comparisons adjusted for HPV status.RESULTS: High intake of foods rich in vitamin A, and particularly high-retinol foods, were associated with a reduced risk ofin-situdisease and less strongly also with a reduced risk of invasive as compared toin-situdisease. No association was found between intake of cruciferous vegetables, foods high in vitamin C, folate, vitamin E, and β-carotene and risk of eitherin-situor invasive cervical cancer.CONCLUSIONS: Increasing intake of foods rich in total vitamin A, and particularly high-retinol foods, may reduce risk ofin-situcervical cancer, and at the highest level of intake may inhibit progression to invasion. If others confirm these results they suggest means of reducing the risk of cervical cancer that are amenable to public health action.
