Amyloid-β efflux from the central nervous system into the plasma.
Amyloid-β efflux from the central nervous system into the plasma.
复制标题
中枢神经系统进入血浆的淀粉样蛋白-β外排。
DOI：
10.1002/ana.24270
复制
发表时间：
2014-12
影响因子：
11.2
通讯作者：
Bateman, Randall J.
中科院分区：
文献类型：
--
作者：
Roberts, Kaleigh Filisa;Elbert, Donald L.;Kasten, Tom P.;Patterson, Bruce W.;Sigurdson, Wendy C.;Connors, Rose E.;Ovod, Vitaliy;Munsell, Ling Y.;Mawuenyega, Kwasi G.;Miller-Thomas, Michelle M.;Moran, Christopher J.;Cross, Dewitte T., III;Derdeyn, Colin P.;Bateman, Randall J.
本研究的目的是测量淀粉样蛋白-β(A-β)在人脑毛细血管床上的流量，以确定转运到血液中是否是清除中枢神经系统产生的A-β的重要机制。同时从大脑静脉(包括乙状窦、岩下窦和颈内静脉)、股静脉和桡动脉采集时间匹配的血样进行岩下窦采样(IPSS)。对每个血浆样本，用三种方法测定A-β浓度，并测定静脉-动脉A-β浓度比。离开中枢神经系统毛细血管床的静脉血中的Aβ浓度比动脉血高约7.5%，这表明从中枢神经系统流出到外周血液中(p<；0.0001)。外周静脉A-β浓度与动脉血浓度比较无差异。我们的结果与中枢神经系统来源的Aβ进入静脉血供的清除是一致的，而没有从外周毛细血管床增加。模拟这些结果表明，Aβ通过血脑屏障的直接转运约占Aβ清除的25%，脑脊液Aβ的重吸收约占人类中枢神经系统Aβ清除的约25%。
The aim of this study was to measure the flux of amyloid-β (Aβ) across the human cerebral capillary bed in order to determine if transport into the blood is a significant mechanism of clearance for Aβ produced in the central nervous system (CNS). Time-matched blood samples were simultaneously collected from a cerebral vein (including the sigmoid sinus, inferior petrosal sinus, and the internal jugular vein), femoral vein, and radial artery of patients undergoing Inferior Petrosal Sinus Sampling (IPSS). For each plasma sample, Aβ concentration was assessed by three assays and the venous to arterial Aβ concentration ratios were determined. Aβ concentration was increased by ~7.5% in venous blood leaving the CNS capillary bed compared to arterial blood, indicating efflux from the CNS into the peripheral blood (p < 0.0001). There was no difference in peripheral venous Aβ concentration compared to arterial blood concentration. Our results are consistent with clearance of CNS-derived Aβ into the venous blood supply with no increase from a peripheral capillary bed. Modeling these results suggests that direct transport of Aβ across the blood-brain barrier accounts for ~25% of Aβ clearance, and reabsorption of cerebrospinal fluid Aβ accounts for ~25% of the total CNS Aβ clearance in humans.
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DOI：
10.1152/ajpendo.00489.2003
发表时间：
2004-05-01
影响因子：
5.1
作者：
Eikelis, N;Lambert, G;Esler, M
通讯作者：
Esler, M
影响因子：
--
作者：
Mehta, PD;Pirttilä, T;Wisniewski, HM
通讯作者：
Wisniewski, HM
影响因子：
82.9
作者：
Bateman, Randall J.;Munsell, Ling Y.;Holtzman, David M.
通讯作者：
Holtzman, David M.
影响因子：
82.9
作者：
Deane, R;Yan, SD;Zlokovic, B
通讯作者：
Zlokovic, B
DOI：
10.1073/pnas.83.4.1140
发表时间：
1986-02-01
影响因子：
11.1
作者：
FOX, PT;RAICHLE, ME
通讯作者：
RAICHLE, ME