Comparative severe dermatologic toxicities of immune checkpoint inhibitors in malignant melanoma: A systematic review and network meta‐analysis
Comparative severe dermatologic toxicities of immune checkpoint inhibitors in malignant melanoma: A systematic review and network meta‐analysis
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DOI：
10.1111/jocd.16105
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发表时间：
2023-11
影响因子：
2.3
通讯作者：
Yun-Tao Mao;Ying Wang;Xiao-Xiao Chen-Xiao;Cheng-Jiang Liu;Qi Bao
中科院分区：
文献类型：
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作者：
Yun-Tao Mao;Ying Wang;Xiao-Xiao Chen-Xiao;Cheng-Jiang Liu;Qi Bao
免疫检查点抑制剂（ICIs）已经推进了恶性黑色素瘤患者的治疗前景。然而，它们可引起永久性和不可逆的皮肤免疫相关不良事件（irAEs），可能导致ICI治疗中断或危及生命。为了评估晚期黑色素瘤ICIs患者发生严重皮肤病irae（3级或更高）的风险，我们进行了网络meta分析（NMA）。
Immune checkpoint inhibitors (ICIs) have advanced the therapeutic landscape for malignant melanoma patients. However, they can cause permanent and irreversible dermatologic immune‐related adverse events (irAEs) that may lead to interruption of ICI treatment or become life‐threatening. To assess the risk of severe dermatologic irAEs (grade 3 or higher) among ICIs for advanced melanoma, we conducted a network meta‐analysis (NMA).