Coinfection with Plasmodium falciparum and Schistosoma haematobium:: Protective effect of schistosomiasis on malaria in Senegalese children?
Coinfection with Plasmodium falciparum and Schistosoma haematobium:: Protective effect of schistosomiasis on malaria in Senegalese children?
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DOI：
10.4269/ajtmh.2005.72.702
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发表时间：
2005-06-01
影响因子：
3.3
通讯作者：
Cot, M
中科院分区：
文献类型：
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作者：
Briand, V;Watier, L;Cot, M
对动物模型的研究表明，在并发感染期间，寄生虫之间可能存在相互作用，并提出了在人类中存在类似现象的问题。本调查旨在评估泌尿系统血吸虫病对儿童疟疾易感性的影响。2001年9月至2002年3月在塞内加尔对523名3至15岁的儿童进行了这项研究。我们测试了恶性疟原虫密度和负荷的埃及血吸虫自我排泄使用线性混合模型之间的关联，因为数据是不独立的。在控制年龄、性别、季节等因素后，我们发现，儿童轻度感染S。感染埃及血吸虫（1-9个卵/10 mL尿液）的恶性疟原虫密度低于未感染的（β =-0.34，95%置信区间=-0.85，-0.10），表明两种寄生虫之间存在负相互作用。
Studies with animal models have suggested the possibility of interactions between parasites during concurrent infections and have raised the question of a similar phenomenon in humans. The present survey was undertaken to assess the impact of urinary schistosomiasis on the susceptibility of children to malaria. It was carried out in Senegal between September 2001 and March 2002 among 523 children 3-15 years of age. We tested the association between Plasmodium falciparum densities and the load of Schistosoma haematobium ego excretion using a linear mixed model because data were not independent. After controlling for age, sex, and season, we showed that children lightly infected with S. haematobium (1-9 eggs/10 mL of urine) had lower P. falciparum densities than those not infected (beta = -0.34, 95% confidence interval = -0.85, -0.10), suggesting a negative interaction between both parasites.