Central nervous system involvement in hepatitis C virus infection
Central nervous system involvement in hepatitis C virus infection
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DOI：
10.1023/b:mebr.0000043983.42843.ac
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发表时间：
2004-12-01
影响因子：
3.6
通讯作者：
Taylor-Robinson, SD
中科院分区：
文献类型：
--
作者：
Forton, DM;Thomas, HC;Taylor-Robinson, SD
肝性脑病是慢性丙型肝炎病毒（HCV）感染最明显的神经系统后果。也有hcv相关脑血管炎的病例报告。本综述关注HCV对脑功能障碍的影响的可能性，这种影响发生在慢性感染的早期阶段，在肝硬化发展之前，与血管炎无关。有新的证据表明，HCV感染中存在轻微但显著的神经认知障碍，这不能归因于药物滥用、共存抑郁或肝性脑病。体内磁共振波谱和神经生理学研究表明，生物学机制可能是这些认知发现的基础。最近在死后脑组织中检测到的HCV基因序列提出了一种有趣的可能性，即HCV感染中枢神经系统可能与报道的神经心理症状和认知障碍有关。
Hepatic encephalopathy is the most obvious neurological consequence of chronic hepatitis C virus (HCV) infection. There are also case reports of HCV-associated cerebral vasculitis. This review is concerned with the possibility of an effect of HCV on cerebral dysfunction, occurring at an early stage of chronic infection, prior to the development of cirrhosis and unrelated to vasculitis. There is emerging evidence of mild, but significant neurocognitive impairment in HCV infection, which cannot be attributed to substance abuse, coexistent depression, or hepatic encephalopathy. In vivo magnetic resonance spectroscopy and neurophysiological studies have suggested that a biological mechanism may underlie these cognitive findings. The recent detection of HCV genetic sequences in postmortem brain tissue raises the intriguing possibility that HCV infection of the central nervous system may be related to the reported neuropsychological symptoms and cognitive impairment.