[Acute myelitis associated with anti-neutral glycolipid antibody].
[Acute myelitis associated with anti-neutral glycolipid antibody].
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DOI：
10.5692/clinicalneurol.cn-001219
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发表时间：
2019-01-30
期刊：
影响因子：
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通讯作者：
Mutoh, Tatsuro
中科院分区：
文献类型：
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作者：
Terasawa, Hideo;Shimuzu, Hirotaka;Mutoh, Tatsuro
一名 48 岁男性突然发烧，在一周内出现急性脊髓炎。脊髓 MRI 显示纵向 T2 高信号椎管内病变，从 C6 延伸至 Th8 水平。临床症状和检查结果通过免疫疗法得到解决。血清学分析未检测到与各种胶原病相关的抗体、抗水通道蛋白4（AQP4）抗体和抗髓磷脂少突胶质细胞糖蛋白（MOG）抗体。急性期血清和脑脊液中检测到抗乳糖神经酰胺（LacCer）抗体，恢复期滴度下降。本病例支持以下观点：急性脊髓炎可以作为抗中性糖脂抗体相关疾病发生。在未来相关的脊髓炎病例中应检查抗中性糖脂抗体。
A 48-year-old man with rapid onset of fever elevation developed acute myelitis over a period of a week. MRI of the spinal cord revealed a longitudinal T2-hyperintense intraspinal lesion extending from C6 to Th8 level. Clinical symptoms and findings resolved with immunotherapy. In serological analysis, no antibodies related to various collagen diseases, anti-aquaporin-4 (AQP4) antibody and anti-myelin oligodendrocyte glycoprotein (MOG) antibody were detected. Anti-lactosylceramide (LacCer) antibodies were detected in the acute phase of serum and cerebrospinal fluid, with titers showing decrements in the recovery phase. The present case supports the notion that acute myelitis can occur as an anti-neutral glycolipid antibody-related disorder. Anti-neutral glycolipid antibodies should be examined in future pertinent cases of myelitis.