New aspect in cartilage growth "the invasive interstitial type".
New aspect in cartilage growth "the invasive interstitial type".
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软骨生长的新方面“侵入性间质型”。
DOI：
10.4172/2155-9546.1000253
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
S. Soliman
中科院分区：
文献类型：
--
作者：
S. Soliman
透明软骨的生长是通过软骨细胞分裂“间质型生长”或通过间充质细胞的软骨周细胞分化为分化的软骨细胞来实现的，分化的软骨细胞沉积连续的软骨基质周向层“并置生长”。目前的研究是为了说明鲶鱼呼吸空气的树突状器官发育过程中第三种类型的软骨生长。为了进行这项研究，从鲶鱼（Clarias garie-pinus）中采集了呼吸空气的树突器官样本。通过光学显微镜检查福尔马林固定标本的石蜡切片。在鲶鱼呼吸空气器官的发育过程中，软骨形成的巢穴以间充质细胞的凝结为代表。一些细胞分化为软骨细胞，形成多个被软骨膜包围的间充质组织包围的软骨岛。周围的间充质细胞进一步分化为软骨细胞，以完成发育中的弹性软骨单位。具有软骨细胞潜能的额外间充质细胞在多个部位侵入软骨以在间质中生长软骨块。此外，由于软骨细胞死亡而空出的腔隙部位发生间质间充质分化，然后取代透明细胞。透明软骨发生间质间质浸润，被弹力型软骨取代。间充质细胞的侵入性间质分化有助于软骨生长、更新和替换。研究间充质细胞侵袭性分化的分子调控可能为解决软骨疾病问题的研究提供有用的指导。
Growth of hyaline cartilage is achieved either by chondrocyte division “interstitial type of growth” or by perichondrial cell differentiation of mesenchymal cells to differentiated chondrocytes which deposit successive circumferential layers of cartilage matrix “appositional growth”. The current study was carried out to illustrate a third type of cartilage growth during development of the air breathing dendritic organ of catfish. To perform this study, samples of the air breathing dendritic organ were collected from catfish (Clarias garie-pinus). Paraffin sections of formalin fixed specimens were examined by light microscopy. During development of the air breathing organ of catfish, the nidus of cartilage formation was represented by a condensation of mesenchymal cells. Some cells differentiate to chondrocytes to form multiple cartilage islets surrounded by mesenchymal tissue which was enclosed by perichondrium. The surrounding mesenchymal cells further on differentiate to chondrocytes to complete the developing elastic cartilaginous unit. Additional mesenchymal cells with chondrocyte potential invade the cartilage at multiple sites to grow the cartilaginous mass interstitially. Moreover, interstitial mesenchymal differentiation occurred at the sites of the vacated lacunae which resulted from the death of chondrocytes and then replaces the hyaline. Interstitial mesenchymal invasion occurred in the hyaline cartilage to be replaced by elastic type. The invasive interstitial differentiation of the mesenchymal cells contributed in cartilage growth, renewal, and replacement. Studying the molecular regulation of the invasive differentiation of the mesenchymal cells may be a useful guide in researches to resolve cartilage disorders problems.