Structural compartmentalization of MHC class II signaling function.
Structural compartmentalization of MHC class II signaling function.
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MHC II 类信号传导功能的结构划分。
DOI：
10.1016/0167-5699(93)90184-m
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
Cambier,JC
中科院分区：
文献类型：
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作者：
Wade,WF;Davoust,J;Salamero,J;Andre,P;Watts,TH;Cambier,JC
主要组织相容性复合体 (MHC) II 类分子是胸腺依赖性免疫反应产生的关键限制因素。最近的研究表明，除了提供 T-ceU 抗原受体识别的复合表位外，MHC II 类分子还通过与其他 celhdar 蛋白相互作用而在信号转导中发挥作用。突变分析表明这些功能所需的结构信息被划分在分子复合物的不同方面。在这里，William Wade 及其同事回顾了 I-Act 和-[3 链中定义的 MHC II 类功能的结构基础。针对蛋白质抗原 (Ag) 的抗体 (Ab) 反应的产生需要 Ag 呈递细胞 (APC) 和 T 细胞的物理相互作用。 B 细胞是一种高效的 APC，因为它能够通过其 Ag 特异性受体浓缩 Ag，并表达各种刺激 T 细胞的辅助配体。 T 和 B 淋巴细胞之间相互作用的特异性由与 B 细胞主要组织相容性复合体 (MHC) II 类分子和 T 细胞 Ag 特异性受体 (TCR) 结合的 Ag 肽片段决定。由 MHC II 类和 TCR 介导的 Ag 特异性相互作用可导致
Major histocompatibility complex (MHC) class II molecules are critical restricting elements in the generation of thymus-dependent immune responses. Recent studies indicate that in addition to providing a composite epitope for recognition by T-ceU antigen receptors, MHC class II molecules function in signal transduction through interaction with other celhdar proteins. Mutational analyses indicate that structural information necessary for these functions is compartmentalized in different aspects of the molecular complex. Here, William Wade and colleagues review the structual basis of this MHC class II function as defined in the I-Act and-[3 chains.Generation of antibody (Ab) responses to protein antigens (Ag) requires the physical interaction of Ag presenting cells (APC) and T cells. The B cell is an efficient APC because of its ability to concentrate Ag via its Ag-specific receptors and its expression of various accessory ligands which stimulate T cells. The specificity of the interaction between T and B lymphocytes is determined by peptide fragments of Ag bound to B-cell major histocompatibility complex (MHC) class II molecules and the T-cell Ag-specific receptor (TCR). Agspecific interaction mediated by MHC class II and TCR can lead to the activation and proliferation of